Should children with inherited metabolic disorders receive varicella vaccination?
Varghese, M Cafferkey, M O'Regan, M Monavari, A A Treacy, E P
Varghese, M
Cafferkey, M
O'Regan, M
Monavari, A A
Treacy, E P
Advisors
Editors
Other Contributors
Date
2011-01
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adolescent
Chickenpox
Chickenpox Vaccine
Child
Child, Preschool
Hospitalization
Humans
Infant
Ireland
Metabolism, Inborn Errors
Vaccination
Chickenpox
Chickenpox Vaccine
Child
Child, Preschool
Hospitalization
Humans
Infant
Ireland
Metabolism, Inborn Errors
Vaccination
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
The aim was to determine the rate of varicella infection and complications in children with disorders of intermediary metabolism (IEM) between the ages of 1 and 16 years attending our national metabolic referral centre. Of 126 children identified, a response was received from 122. A history of previous varicella infection was identified in 64 cases (53%) and of varicella vaccination in 5 (4%). Fifty-three (43%) patients apparently did not have a history of clinical varicella infection. Of the 64 children with a history of varicella infection, five required hospitalisation for complications, including life-threatening lactic acidosis in one patient with mitochondrial disease and metabolic decompensation in four patients. In conclusion, varicella infection may cause an increased risk of metabolic decompensation in patients with IEMs. We propose that a trial of varicella vaccination be considered for this cohort of patients with monitoring of its safety and efficacy.
Language
en
ISSN
1468-2044
eISSN
ISBN
DOI
10.1136/adc.2008.147934
PMID
19846994