The use of bone morphogenetic protein 7 in fracture non-unions.
O'hEireamhoin, Sven Quinlan, John F Rourke, Kieran O
O'hEireamhoin, Sven
Quinlan, John F
Rourke, Kieran O
Advisors
Editors
Other Contributors
Date
2011-02
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Aged
Aged, 80 and over
Bone Morphogenetic Protein 7
Drug Evaluation
Female
Femoral Fractures
Follow-Up Studies
Fracture Healing
Fractures, Ununited
Humans
Humeral Fractures
Male
Middle Aged
Retrospective Studies
Tibial Fractures
Treatment Outcome
Aged
Aged, 80 and over
Bone Morphogenetic Protein 7
Drug Evaluation
Female
Femoral Fractures
Follow-Up Studies
Fracture Healing
Fractures, Ununited
Humans
Humeral Fractures
Male
Middle Aged
Retrospective Studies
Tibial Fractures
Treatment Outcome
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
To assess the rate of clinical and radiological union with the use of bone morphogenetic protein 7 (BMP-7) in a range of fractures.
This case series retrospectively reviews a series of 16 fracture non-unions in 13 patients. These patients were treated with the commercially available BMP-7. Time to radiological and clinical union was assessed by serial out-patient follow-up.
At nine months post-surgery in which BMP-7 was added, 12 of 16 non-unions had achieved clinical and radiographic union. Three patients required repeat grafting. The mean time to union was 5.1 ± 1.6 months after the application of BMP-7.
The use of the osteo-inductive agent, BMP-7 results in good clinical and radiological outcomes which are not restricted to tibial non-unions.
This case series retrospectively reviews a series of 16 fracture non-unions in 13 patients. These patients were treated with the commercially available BMP-7. Time to radiological and clinical union was assessed by serial out-patient follow-up.
At nine months post-surgery in which BMP-7 was added, 12 of 16 non-unions had achieved clinical and radiographic union. Three patients required repeat grafting. The mean time to union was 5.1 ± 1.6 months after the application of BMP-7.
The use of the osteo-inductive agent, BMP-7 results in good clinical and radiological outcomes which are not restricted to tibial non-unions.
Language
en
ISSN
1757-7861
eISSN
ISBN
DOI
10.1111/j.1757-7861.2010.00119.x
PMID
22009979
PMCID
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Ethical Approval
N/A