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Antimicrobial PAA/PAH Electrospun Fiber Containing Green Synthesized Zinc Oxide Nanoparticles for Wound Healing.
Bandeira, Marina Chee, Bor Shin Frassini, Rafaele Nugent, Michael Giovanela, Marcelo Roesch-Ely, Mariana Crespo, Janaina da Silva Devine, Declan M
Bandeira, Marina
Chee, Bor Shin
Frassini, Rafaele
Nugent, Michael
Giovanela, Marcelo
Roesch-Ely, Mariana
Crespo, Janaina da Silva
Devine, Declan M
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Date
2021-05-27
Date Submitted
Keywords
Antimicrobial
electrospinning
polymer fiber
wound healing
zinc oxide nanoparticles
electrospinning
polymer fiber
wound healing
zinc oxide nanoparticles
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materials-14-02889-v2.pdf
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Abstract
Wound infections are the main complication when treating skin wounds. This work reports a novel antimicrobial material using green synthesized zinc oxide nanoparticles (ZnONPs) incorporated in polymeric fibers for wound healing purposes. ZnONPs are a promising antimicrobial nanomaterial with high activity against a range of microorganisms, including drug-resistant bacteria. The electrospun fibers were obtained using polyacrylic acid (PAA) and polyallylamine hydrochloride (PAH) and were loaded with ZnONPs green synthesized from Ilex paraguariensis leaves with a spherical shape and ~18 nm diameter size. The fibers were produced using the electrospinning technique and SEM images showed a uniform morphology with a diameter of ~230 nm. EDS analysis proved a consistent dispersion of Zn in the fiber mat, however, particle agglomerates with varying sizes were observed. FTIR spectra confirmed the interaction of PAA carboxylic groups with the amine of PAH molecules. Although ZnONPs presented higher antimicrobial activity against S. aureus than E. coli, resazurin viability assay revealed that the PAA/PAH/ZnONPs composite successfully inhibited both bacteria strains growth. Photomicrographs support these results where bacteria clusters were observed only in the control samples. The PAA/PAH/ZnONPs composite developed presents antimicrobial activity and mimics the extracellular matrix morphology of skin tissue, showing potential for wound healing treatments.
Language
en
Citation
ISSN
1996-1944
eISSN
ISBN
DOI
10.3390/ma14112889
PMID
34072271