Effects of oral cetirizine, a selective H1 antagonist, on allergen- and exercise-induced bronchoconstriction in subjects with asthma.
Gong, H Tashkin, D P Dauphinee, B Djahed, B Wu, T C
Gong, H
Tashkin, D P
Dauphinee, B
Djahed, B
Wu, T C
Advisors
Editors
Other Contributors
Date
1990-03
Date Submitted
Keywords
Other Subjects
Subject Mesh
Administration, Oral
Adult
Albuterol
Allergens
Asthma
Asthma, Exercise-Induced
Bronchi
Bronchial Provocation Tests
Cetirizine
Constriction, Pathologic
Dose-Response Relationship, Drug
Double-Blind Method
Forced Expiratory Volume
Histamine H1 Antagonists
Humans
Hydroxyzine
Peak Expiratory Flow Rate
Randomized Controlled Trials as Topic
Adult
Albuterol
Allergens
Asthma
Asthma, Exercise-Induced
Bronchi
Bronchial Provocation Tests
Cetirizine
Constriction, Pathologic
Dose-Response Relationship, Drug
Double-Blind Method
Forced Expiratory Volume
Histamine H1 Antagonists
Humans
Hydroxyzine
Peak Expiratory Flow Rate
Randomized Controlled Trials as Topic
Planned Date
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Abstract
The protective efficacy of oral cetirizine, a selective and potent H1-receptor antagonist, against the immediate bronchoconstrictive response to allergen inhalation and exercise challenge was evaluated in 16 subjects with stable, predominantly mild asthma. The subjects underwent double-blind, crossover pretreatments in randomized order in two separate protocols with (1) three daily oral doses of 20 mg of cetirizine and placebo, followed by allergen inhalation, and (2) single oral doses of cetirizine (5, 10, and 20 mg), albuterol (4 mg), and placebo, followed by exercise with cold-air inhalation. Cetirizine failed to decrease bronchial sensitivity to inhaled allergen in eight of 10 subjects. Neither cetirizine nor albuterol uniformly inhibited exercise-induced bronchoconstriction. Serum concentrations of cetirizine were consistent with systemic H1-blocking activity. Modest bronchodilation occurred after administration of cetirizine and albuterol before exercise but not after the third dose of cetirizine in the allergen protocol. One subject developed moderate drowsiness during multiple dosing with cetirizine. Thus, cetirizine, in the doses studied, is not uniformly effective in preventing allergen- or exercise-induced bronchoconstriction. Histamine is one of many mediators participating in immediate asthmatic responses, and selective H1 antagonists do not completely block these airway events. However, cetirizine may still clinically benefit some patients with asthma, such as patients with allergic rhinitis or urticaria.
Language
en
ISSN
0091-6749
eISSN
ISBN
DOI
PMID
1968919
PMCID
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Ethical Approval
N/A