Variation in the vitamin D receptor gene is not associated with risk of colorectal cancer in the Czech Republic.
Hughes, David J Hlavata, Ivona Soucek, Pavel Pardini, Barbara Naccarati, Alessio Vodickova, Ludmila Jenab, Mazda Vodicka, Pavel
Hughes, David J
Hlavata, Ivona
Soucek, Pavel
Pardini, Barbara
Naccarati, Alessio
Vodickova, Ludmila
Jenab, Mazda
Vodicka, Pavel
Advisors
Editors
Other Contributors
Date
2012-02-01T10:49:22Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Aged
Aged, 80 and over
Case-Control Studies
Colon/metabolism
Colorectal Neoplasms/*genetics
Czech Republic
DNA/genetics
Female
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic/*genetics
Prognosis
Receptors, Calcitriol/*genetics
Rectum/metabolism
Risk Factors
Vitamin D/metabolism
Aged
Aged, 80 and over
Case-Control Studies
Colon/metabolism
Colorectal Neoplasms/*genetics
Czech Republic
DNA/genetics
Female
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic/*genetics
Prognosis
Receptors, Calcitriol/*genetics
Rectum/metabolism
Risk Factors
Vitamin D/metabolism
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
PURPOSE: Increased levels of vitamin D may protect against colorectal cancer (CRC) development and recurrence. Accumulating epidemiologic evidence suggests these effects may be partly mediated by genetic variants of the vitamin D receptor (VDR) proposed to be associated with altered risk of CRC. We wished to determine if common VDR polymorphisms affected CRC risk in the Czech Republic, a homogenous European population with a high CRC incidence rate. METHODS: Frequencies of the common VDR gene polymorphisms rs2238136, rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI) were determined using allele-specific PCR in a case control analysis of a series of 754 CRC patients and 627 patients without malignant disease recruited from centers throughout the Czech Republic. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association between these variants and risk of CRC. RESULTS: None of the four polymorphisms tested had any significant effect on CRC risk. No significant differences were observed in susceptibility when the population was stratified by anatomical sub-site, sex, BMI, smoking, alcohol, or presence of polyps. CONCLUSIONS: We conclude that common variation in the VDR gene had little effect on its own on predisposition to sporadic CRC in the Czech population.
Language
eng
ISSN
1941-6636 (Electronic)
eISSN
ISBN
DOI
10.1007/s12029-010-9168-6
PMID
20585998