Psoriatic arthritis: from pathogenesis to therapy.
Fitzgerald, Oliver Winchester, Robert
Fitzgerald, Oliver
Winchester, Robert
Advisors
Editors
Other Contributors
Date
2012-02-01T10:34:33Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Arthritis, Psoriatic/*genetics/*immunology/*therapy
Genetic Predisposition to Disease
Humans
Immunologic Factors/therapeutic use
Genetic Predisposition to Disease
Humans
Immunologic Factors/therapeutic use
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Psoriatic arthritis is a multigenic autoimmune disease that involves synovial tissue, entheseal sites and skin, and that may result in significant joint damage. Although there are no diagnostic tests for psoriatic arthritis, research has identified consistent features that help to distinguish the condition from other common rheumatic diseases. Comparison of HLA-B and HLA-C regions in psoriatic arthritis with those in psoriasis without joint involvement demonstrates significant differences, such that psoriatic arthritis cannot be viewed simply as a subset of genetically homogeneous psoriasis. T-cell receptor phenotypic studies have failed to identify antigen-driven clones, and an alternative hypothesis for CD8 stimulation involving innate immune signals is proposed. Finally, imaging studies have highlighted entheseal involvement in psoriatic arthritis, and it is possible that entheseal-derived antigens may trigger an immune response that is critically involved in disease pathogenesis.
Language
eng
ISSN
1478-6362 (Electronic)
1478-6354 (Linking)
1478-6354 (Linking)
eISSN
ISBN
DOI
10.1186/ar2580
PMID
19232079