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Clinical observations associated with proven and unproven cases in the ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery.
Barry, Peter Gardner, Susanne Seal, David Gettinby, George Lees, Fiona Peterson, Magnus Revie, Crawford
Barry, Peter
Gardner, Susanne
Seal, David
Gettinby, George
Lees, Fiona
Peterson, Magnus
Revie, Crawford
Advisors
Editors
Other Contributors
Date
2012-02-01T10:40:10Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Aged
Aged, 80 and over
Anti-Bacterial Agents/therapeutic use
Cefuroxime/therapeutic use
Endophthalmitis/*diagnosis/drug therapy/microbiology
Eye Diseases/*diagnosis
Eye Infections, Bacterial/*diagnosis/drug therapy/microbiology
Eyelid Diseases/*diagnosis
Female
Humans
Lens Implantation, Intraocular
Male
Middle Aged
Pain/*diagnosis
Phacoemulsification
Polymerase Chain Reaction
*Postoperative Complications
Time Factors
Visual Acuity
Vitreous Body/*pathology
Aged, 80 and over
Anti-Bacterial Agents/therapeutic use
Cefuroxime/therapeutic use
Endophthalmitis/*diagnosis/drug therapy/microbiology
Eye Diseases/*diagnosis
Eye Infections, Bacterial/*diagnosis/drug therapy/microbiology
Eyelid Diseases/*diagnosis
Female
Humans
Lens Implantation, Intraocular
Male
Middle Aged
Pain/*diagnosis
Phacoemulsification
Polymerase Chain Reaction
*Postoperative Complications
Time Factors
Visual Acuity
Vitreous Body/*pathology
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
PURPOSE: To describe cases of postoperative endophthalmitis in the European Society of Cataract & Refractive Surgeons (ESCRS) study of the prophylaxis of endophthalmitis, compare characteristics of unproven cases and cases proven by culture or polymerase chain reaction, and compare the characteristics with those in other reported series. SETTING: Twenty-four ophthalmology units in Austria, Belgium, Germany, Italy, Poland, Portugal, Spain, Turkey, and the United Kingdom. METHODS: Univariable and multivariable logistic regression models were used to analyze data for statistical association of signs and symptoms in cases with proven or unproven endophthalmitis. Specific data describing characteristics of the cases were compared between the 2 types of cases. RESULTS: Data from 29 endophthalmitis cases were analyzed. Swollen lids and pain were statistically associated with proven cases of endophthalmitis on univariable regression analysis. Multivariable analysis indicated that swollen lids and an opaque vitreous were associated with proven cases. Five cases of endophthalmitis occurred in the cefuroxime-treated groups. No case of streptococcal infection occurred in the cefuroxime-treated groups. However, cases of infection due to streptococci showed striking differences in visual acuity and were associated with earlier onset. Characteristics in the 29 cases parallel results in previous studies, such as the Endophthalmitis Vitrectomy Study, although the addition of a control group in the ESCRS study elicited additional findings. CONCLUSION: Swollen lids, pain, and an opaque vitreous were statistically associated with proven endophthalmitis cases in the ESCRS study.
Language
eng
ISSN
1873-4502 (Electronic)
0886-3350 (Linking)
0886-3350 (Linking)
eISSN
ISBN
DOI
10.1016/j.jcrs.2009.03.049
PMID
19683148