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Crohn's disease.
Shanahan, Fergus
Shanahan, Fergus
Author
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Date
2012-02-03T15:10:55Z
Date Submitted
Keywords
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Subject Mesh
Animals
*Carrier Proteins
*Crohn Disease/genetics/immunology/microbiology
Genetic Predisposition to Disease
Humans
Intestines/immunology/microbiology
*Intracellular Signaling Peptides and Proteins
Nod2 Signaling Adaptor Protein
Proteins/genetics
*Carrier Proteins
*Crohn Disease/genetics/immunology/microbiology
Genetic Predisposition to Disease
Humans
Intestines/immunology/microbiology
*Intracellular Signaling Peptides and Proteins
Nod2 Signaling Adaptor Protein
Proteins/genetics
Planned Date
Start Date
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Abstract
Crohn's disease is a disorder mediated by T lymphocytes which arises in genetically susceptible individuals as a result of a breakdown in the regulatory constraints on mucosal immune responses to enteric bacteria. Regulation of immune reactivity to enteric antigens has improved understanding of the pathophysiological mechanisms of Crohn's disease, and has expanded therapeutic options for patients with this disorder. Disease heterogeneity is probable, with various underlying defects associated with a similar pathophysiological outcome. Although most conventional drug treatments are directed at modification of host response, therapeutic manipulation of the enteric flora is becoming a realistic option.
Language
eng
Citation
ISSN
0140-6736 (Print)
0140-6736 (Linking)
0140-6736 (Linking)
eISSN
ISBN
DOI
10.1016/S0140-6736(02)07284-7
PMID
11809204