Severe deterioration of psoriasis due to an insulinoma.
Field, S Kelly, G Tobin, A-M Barragry, J M Conlon, K C Kirby, B
Field, S
Kelly, G
Tobin, A-M
Barragry, J M
Conlon, K C
Kirby, B
Advisors
Editors
Other Contributors
Date
2008-03
Date Submitted
Keywords
Other Subjects
Subject Mesh
Female
Humans
Hypoglycemia
Insulinoma
Middle Aged
Pancreatectomy
Pancreatic Hormones
Psoriasis
Treatment Outcome
Humans
Hypoglycemia
Insulinoma
Middle Aged
Pancreatectomy
Pancreatic Hormones
Psoriasis
Treatment Outcome
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
We report a case of a 56-year-old woman who presented with a severe exacerbation of psoriasis with concurrent hypoglycaemic episodes. Methotrexate 17.5 mg weekly was required to control her psoriasis. Investigation of her hypoglycaemia showed raised levels of insulin, C-peptide and proinsulin. Radiological investigation showed a tumour at the tail of the pancreas and the diagnosis was insulinoma. A spleen-preserving distal pancreatectomy was performed and the hypoglycaemic symptoms resolved. Immediately following the pancreatectomy, methotrexate was stopped and the patient's psoriasis went into remission. During a 2-year follow-up, she has required only minimal topical treatment for her skin.
Language
en
ISSN
0307-6938
eISSN
ISBN
DOI
10.1111/j.1365-2230.2007.02578.x
PMID
18076690