Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis.
Ji, G-R Yao, M Sun, C-Y Zhang, L Han, Z
Ji, G-R
Yao, M
Sun, C-Y
Zhang, L
Han, Z
Advisors
Editors
Other Contributors
Date
2012-01-06T15:44:39Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Aged
Aged, 80 and over
Binding Sites
Collagen Type I
European Continental Ancestry Group
Female
Fractures, Bone
Genetic Predisposition to Disease
Humans
Middle Aged
Osteoporosis
Polymorphism, Genetic
Postmenopause
Sp1 Transcription Factor
Aged, 80 and over
Binding Sites
Collagen Type I
European Continental Ancestry Group
Female
Fractures, Bone
Genetic Predisposition to Disease
Humans
Middle Aged
Osteoporosis
Polymorphism, Genetic
Postmenopause
Sp1 Transcription Factor
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
This study was designed to summarize quantitatively the evidence for a relationship between collagen type I alpha1 (COLIA1) Sp1 polymorphism and osteoporotic fracture risk in Caucasian post-menopausal women. This meta-analysis included 16 studies, which analysed 2294 patients with fractures and 10 285 controls. The combined results showed that there was a significant difference in genotype distribution (SS odds ratio [OR] 0.72; Ss OR 1.18; ss OR 1.97) between patients with fractures and controls. When stratifying by the fracture site, it was found that: (i) patients with vertebral fractures had a significantly higher frequency of the Ss genotype and a lower frequency of the SS genotype than controls; and (ii) patients with non-vertebral fractures had a significantly higher frequency of the ss genotype and a lower frequency of the SS genotype than controls. This meta-analysis suggests that the COLIA1 Sp1 polymorphism may be associated with osteoporotic fracture in Caucasian post-menopausal women.
Language
en
ISSN
0300-0605
eISSN
ISBN
DOI
PMID
20146870