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Delayed villous maturation of the placenta: quantitative assessment in different cohorts.
Treacy, Ann Higgins, Mary Kearney, John M McAuliffe, Fionnuala Mooney, Eoghan E
Treacy, Ann
Higgins, Mary
Kearney, John M
McAuliffe, Fionnuala
Mooney, Eoghan E
Advisors
Editors
Other Contributors
Date
2013
Date Submitted
Keywords
PREGNANCY
OBSTETRICIAN
OBSTETRICIAN
Other Subjects
Subject Mesh
Chorionic Villi
Cohort Studies
Female
Fetal Diseases
Humans
Infant, Newborn
Male
Placenta Diseases
Pregnancy
Stillbirth
Cohort Studies
Female
Fetal Diseases
Humans
Infant, Newborn
Male
Placenta Diseases
Pregnancy
Stillbirth
Planned Date
Start Date
Collaborators
Principal Investigators
Files
Alternative Titles
Publisher
Abstract
Placental villous maturation is maximal in the 3rd trimester, with an abundance of terminal villi. Delayed villous maturation (DVM) of the placenta is associated with chromosomal abnormalities, gestational diabetes, and an adverse outcome. This study compares quantitative assessment of vasculo-syncytial membranes (VSM) in cases of liveborn infants, perinatal deaths, and controls. Cases were selected as follows: (1) liveborn infants with a qualitative diagnosis of DVM (n = 15); (2) controls matched for gestational age whose placentas did not have DVM (n = 15); (3) stillbirths (SB)/neonatal deaths (NND) showing DVM (n = 13); and (4) SB from autopsies in which DVM was felt to be the cause of death (COD) (n = 12). Vasculo-syncytial membranes were counted in 10 terminal villi in each of 10 consecutive high-power fields on 3 slides. Data analysis was carried out using SPSS. Liveborn cases with DVM showed statistically significantly less VSM than controls (mean 1.01 vs 2.42, P < 0.0001). The SB/NND group also showed significantly less VSM than the control group (mean 0.46 vs 2.42, P < 0.0001) and less than the liveborn DVM group (mean 0.46 vs 1.01, P = 0.001). The COD group was significantly different from the control group (mean 0.42 vs 2.42, P < 0.0001) and the liveborn DVM group (mean 0.42 vs 1.01, P < 0.0001) but not significantly different from the SB/NND group. There is a quantitative reduction in VSM in cases of DVM compared to controls.
Language
en
ISSN
1093-5266
eISSN
ISBN
DOI
10.2350/12-06-1218-OA.1
PMID
23137099