Organising pneumonia associated with fumaric acid ester treatment for psoriasis.
Deegan, Alexander Paul Kirby, Brian Rogers, Sarah Crotty, Tom Bernard McDonnell, Timonthy John
Deegan, Alexander Paul
Kirby, Brian
Rogers, Sarah
Crotty, Tom Bernard
McDonnell, Timonthy John
Advisors
Editors
Other Contributors
Date
2012-02-01T10:28:34Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Administration, Oral
Biopsy
Cryptogenic Organizing Pneumonia/diagnosis/drug therapy/*etiology
Fumarates/administration & dosage/*adverse effects
Glucocorticoids/therapeutic use
Humans
Lung Diseases/*chemically induced/diagnosis/drug therapy
Male
Middle Aged
Prednisolone/therapeutic use
Psoriasis/*drug therapy
Tomography, X-Ray Computed
Biopsy
Cryptogenic Organizing Pneumonia/diagnosis/drug therapy/*etiology
Fumarates/administration & dosage/*adverse effects
Glucocorticoids/therapeutic use
Humans
Lung Diseases/*chemically induced/diagnosis/drug therapy
Male
Middle Aged
Prednisolone/therapeutic use
Psoriasis/*drug therapy
Tomography, X-Ray Computed
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
INTRODUCTION: We present the case of a 49-year old male who presented with dyspnoea, cough, weight loss, night sweats and general malaise. He had been on treatment with oral fumaric acid esters (FAE, Fumaderm(R); Biogen Idec GmbH, Ismaning, Germany) for 6 months. METHODS: Report of a case. RESULTS: His chest X-ray showed patchy infiltrates in the left upper lobe which failed to resolve under empiric antibiotic therapy. A computed tomography of thorax revealed bilateral, mostly peripheral foci of consolidation with air bronchograms. Transbronchial biopsies showed a pattern of organising pneumonia (OP). CONCLUSIONS: Therapy with oral prednisolone (40 mg/day) resulted in a rapid clinical and radiological improvement. An association of FAE and OP has not previously been reported. Please cite this paper as: Deegan AP, Kirby B, Rogers S, Crotty TB and McDonnell TJ. Organising pneumonia associated with fumaric acid ester treatment for psoriasis.
Language
eng
ISSN
1752-699X (Electronic)
1752-6981 (Linking)
1752-6981 (Linking)
eISSN
ISBN
DOI
10.1111/j.1752-699X.2009.00180.x
PMID
20887349