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Anti-beta2 glycoprotein 1 and the anti-phospholipid syndrome.
Keane, Pearse A Ravikumar, Kesavan O'shea, Susan I Cleary, Philip E
Keane, Pearse A
Ravikumar, Kesavan
O'shea, Susan I
Cleary, Philip E
Advisors
Editors
Other Contributors
Date
2012-02-03T15:17:33Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Antibodies, Anticardiolipin/blood
Antiphospholipid Syndrome/*diagnosis
Apolipoproteins/*immunology
Autoantibodies/*blood
Blindness/pathology
Glycoproteins/*immunology
Humans
Lupus Coagulation Inhibitor/blood
Male
Middle Aged
Retinal Vein Occlusion/*diagnosis
beta 2-Glycoprotein I
Antiphospholipid Syndrome/*diagnosis
Apolipoproteins/*immunology
Autoantibodies/*blood
Blindness/pathology
Glycoproteins/*immunology
Humans
Lupus Coagulation Inhibitor/blood
Male
Middle Aged
Retinal Vein Occlusion/*diagnosis
beta 2-Glycoprotein I
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
PURPOSE: To describe a patient who presented with bilateral retinal vascular occlusion and the use of anti-beta2 glycoprotein 1 (GPI) antibody testing in the diagnosis of antiphospholipid syndrome. DESIGN: Observational case report. METHODS: Hematological investigations were performed on a 49-year-old man who presented with rapid onset of bilateral severe central retinal vein occlusion. RESULTS: Lupus anticoagulant and anticardiolipin antibody testing was negative. Markedly raised titers of anti-beta2 GPI antibodies were detected on two separate occasions. CONCLUSIONS: The raised titers of anti-beta2 GPI antibodies were considered to strongly suggest an underlying diagnosis of the antiphospholipid syndrome.
Language
eng
ISSN
0002-9394 (Print)
0002-9394 (Linking)
0002-9394 (Linking)
eISSN
ISBN
DOI
10.1016/j.ajo.2006.04.048
PMID
17011877