Elevated serum angiotensin converting enzyme levels in metastatic ovarian dysgerminoma.
Cotter, T P Kealy, N P Duggan, P F Curtain, A Bredin, C P
Cotter, T P
Kealy, N P
Duggan, P F
Curtain, A
Bredin, C P
Advisors
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Other Contributors
Departments
Date
2012-02-03T15:15:13Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Disorders of Sex Development/complications/genetics
Dysgerminoma/enzymology/*secondary/therapy
Female
Humans
Lymphatic Metastasis
Male
Ovarian Neoplasms/*pathology
Peptidyl-Dipeptidase A/*blood
Tumor Markers, Biological/*blood
Disorders of Sex Development/complications/genetics
Dysgerminoma/enzymology/*secondary/therapy
Female
Humans
Lymphatic Metastasis
Male
Ovarian Neoplasms/*pathology
Peptidyl-Dipeptidase A/*blood
Tumor Markers, Biological/*blood
Planned Date
Start Date
Collaborators
Principal Investigators
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Abstract
A case of a 32-year-old XY genotype female is described, presenting with mediastinal and abdominal lymphadenopathy and associated with an elevated serum angiotensin I converting enzyme (SACE) level. Lymph node histology showed a malignant dysgerminoma of ovarian origin. Combined chemotherapy led to a radiological regression of the lymphadenopathy and coincided with a decrease in SACE concentration. The authors suggest that SACE may be a marker for disseminated germinoma tumours and may be useful for monitoring treatment.
Language
eng
Citation
ISSN
0954-6111 (Print)
0954-6111 (Linking)
0954-6111 (Linking)
eISSN
ISBN
DOI
PMID
9156148