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Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q.
Kelly, Kevin Murphy, Philip
Kelly, Kevin
Murphy, Philip
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Author
Advisors
Editors
Other Contributors
Departments
Department of Haematology, Beaumont Hospital, Dublin, Ireland. kevrkelly77@hotmail.com
Date
2008-12
Date Submitted
Keywords
Other Subjects
Subject Mesh
Anemia, Aplastic
Blast Crisis
Bone Marrow
Chromosome Deletion
Chromosomes, Human, Pair 9
Humans
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Young Adult
Blast Crisis
Bone Marrow
Chromosome Deletion
Chromosomes, Human, Pair 9
Humans
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Young Adult
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Aplastic anaemia (AA) can precede acute lymphoblastic leukaemia (ALL) in 2% of children but this is rarely reported to occur in adults. A 21-year-old male presented with bone marrow failure and bone marrow biopsy showed a profoundly hypocellular marrow. He recovered spontaneously but represented 2 months later when he was diagnosed with pre-B acute lymphoblastic leukaemia. Chromosomal examination revealed 46,XY,del(9)(q13q34). To the best of our knowledge this is the first case to be reported of aplasia preceding ALL with 9q minus as the sole chromosomal abnormality.
Language
en
ISSN
0145-2126
eISSN
ISBN
DOI
10.1016/j.leukres.2008.03.012
PMID
18490054