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Neuropsychiatric complications associated with interferon - alpha -2b treatment of malignant melanoma.
Enudi, W Udolu, O J
Enudi, W
Udolu, O J
Author
Advisors
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Date
2009-08
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Antimanic Agents
Antineoplastic Agents
Antipsychotic Agents
Benzodiazepines
Bipolar Disorder
Dose-Response Relationship, Drug
Humans
Interferon Alfa-2b
Male
Melanoma
Skin Neoplasms
Antimanic Agents
Antineoplastic Agents
Antipsychotic Agents
Benzodiazepines
Bipolar Disorder
Dose-Response Relationship, Drug
Humans
Interferon Alfa-2b
Male
Melanoma
Skin Neoplasms
Planned Date
Start Date
Collaborators
Principal Investigators
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19750253.pdf
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Abstract
Several adverse effects have been associated with interferon alpha 2b treatment and neuropsychiatric effects have also been commonly reported. Psychosis and mood disorders have been described in the literature. This case report is of a 30 year old man with malignant melanoma stage 3a who was receiving adjuvant alpha 2b interferon and developed a manic episode two weeks post switching after one month of treatment on a high dose to a low dose. There was no previous psychiatric illness and no known family history of mental illness. This is in keeping with previous reports that mania has been observed in patients undergoing interferon treatment especially after significant dose-reduction or treatment breaks. Mania induced by interferon responds well to antimanic drugs .Since interferon alpha 2b is now commonly used in the treatment of malignant melanoma and other conditions, the need to be aware of its neuropsychiatric complications is essential.
Language
en
ISSN
1994-8220
eISSN
ISBN
DOI
PMID
19750253