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Genioglossus fatigue in obstructive sleep apnea.
McSharry, David O'Connor, Ciara McNicholas, Triona Langran, Simon O'Sullivan, Michael Lowery, Madeleine McNicholas, Walter T
McSharry, David
O'Connor, Ciara
McNicholas, Triona
Langran, Simon
O'Sullivan, Michael
Lowery, Madeleine
McNicholas, Walter T
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Other Contributors
Date
2012-08-15
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Electromyography
Female
Humans
Isometric Contraction
Male
Middle Aged
Muscle Fatigue
Muscle, Skeletal
Neural Conduction
Sleep Apnea, Obstructive
Tongue
Wakefulness
Electromyography
Female
Humans
Isometric Contraction
Male
Middle Aged
Muscle Fatigue
Muscle, Skeletal
Neural Conduction
Sleep Apnea, Obstructive
Tongue
Wakefulness
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Obstructive sleep apnea (OSA) is a prevalent disorder that may cause cardiovascular disease and fatal traffic accidents but the pathophysiology remains incompletely understood. Increased fatigability of the genioglossus (the principal upper airway dilator muscle) might be important in OSA pathophysiology but the existing literature is uncertain. We hypothesized that the genioglossus in OSA subjects would fatigue more than in controls. In 9 OSA subjects and 9 controls during wakefulness we measured maximum voluntary tongue protrusion force (Tpmax). Using surface electromyography arrays we measured the rate of decline in muscle fiber conduction velocity (MFCV) during an isometric fatiguing contraction at 30% Tpmax. The rate of decline in MFCV provides an objective means of quantifying localized muscle fatigue. Linear regression analysis of individual subject data demonstrated a significantly greater decrease in MFCV in OSA subjects compared to control subjects (29.2 ± 20.8% [mean ± SD] versus 11.2 ± 20.8%; p=0.04). These data support increased fatigability of the genioglossus muscle in OSA subjects which may be important in the pathophysiology of OSA.
Language
en
ISSN
1878-1519
eISSN
ISBN
DOI
10.1016/j.resp.2012.05.024
PMID
22677657