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Global genome diversity of the complex.

Franssen, Susanne U
; 
Durrant, Caroline
; 
Stark, Olivia
; 
Moser, Bettina
; 
Downing, Tim
; 
Imamura, Hideo
; 
Dujardin, Jean-Claude
; 
Sanders, Mandy J
; 
Mauricio, Isabel
; 
Miles, Michael A
... show 10 more
Author
Franssen, Susanne U
 Durrant, Caroline
 Stark, Olivia
 Moser, Bettina
 Downing, Tim
 Imamura, Hideo
 Dujardin, Jean-Claude
 Sanders, Mandy J
 Mauricio, Isabel
 Miles, Michael A
 Schnur, Lionel F
 Jaffe, Charles L
 Nasereddin, Abdelmajeed
 Schallig, Henk
 Yeo, Matthew
 Bhattacharyya, Tapan
 Alam, Mohammad Z
 Berriman, Matthew
 Wirth, Thierry
 Schönian, Gabriele
 Cotton, James A
Advisors
Editors
Other Contributors
Departments
Date
2020-03-25
Date Submitted
Keywords
Leishmania donovani / infantum
aneuploidy
GENETICS
GENOMICS
hybridisation
infectious disease
MICROBIOLOGY
neglected tropical disease
visceral leishmaniasis
Other Subjects
Subject Mesh
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Start Date
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elife-51243-v2.pdf
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elife-51243-figures-v2.pdf
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Publisher
URI
https://hdl.handle.net/10147/629526
Abstract
Protozoan parasites of the Leishmania donovani complex - L. donovani and L. infantum - cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome-wide global study, with 151 cultured field isolates representing most of the geographical distribution. L. donovani isolates separated into five groups that largely coincide with geographical origin but vary greatly in diversity. In contrast, the majority of L. infantum samples fell into one globally-distributed group with little diversity. This picture is complicated by several hybrid lineages. Identified genetic groups vary in heterozygosity and levels of linkage, suggesting different recombination histories. We characterise chromosome-specific patterns of aneuploidy and identified extensive structural variation, including known and suspected drug resistance loci. This study reveals greater genetic diversity than suggested by geographically-focused studies, provides a resource of genomic variation for future work and sets the scene for a new understanding of the evolution and genetics of the Leishmania donovani complex.
Language
en
Citation
ISSN
eISSN
2050-084X
ISBN
DOI
10.7554/eLife.51243
PMID
32209228
PMCID
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