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Genetically Determined Height and Risk of Non-hodgkin Lymphoma.

Moore, Amy
; 
Kane, Eleanor
; 
Wang, Zhaoming
; 
Panagiotou, Orestis A
; 
Teras, Lauren R
; 
Monnereau, Alain
; 
Wong Doo, Nicole
; 
Machiela, Mitchell J
; 
Skibola, Christine F
; 
Slager, Susan L
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Author
Moore, Amy
 Kane, Eleanor
 Wang, Zhaoming
 Panagiotou, Orestis A
 Teras, Lauren R
 Monnereau, Alain
 Wong Doo, Nicole
 Machiela, Mitchell J
 Skibola, Christine F
 Slager, Susan L
 Salles, Gilles
 Camp, Nicola J
 Bracci, Paige M
 Nieters, Alexandra
 Vermeulen, Roel C H
 Vijai, Joseph
 Smedby, Karin E
 Zhang, Yawei
 Vajdic, Claire M
 Cozen, Wendy
 Spinelli, John J
 Hjalgrim, Henrik
 Giles, Graham G
 Link, Brian K
 Clavel, Jacqueline
 Arslan, Alan A
 Purdue, Mark P
 Tinker, Lesley F
 Albanes, Demetrius
 Ferri, Giovanni M
 Habermann, Thomas M
 Adami, Hans-Olov
 Becker, Nikolaus
 Benavente, Yolanda
 Bisanzi, Simonetta
 Boffetta, Paolo
 Brennan, Paul
 Brooks-Wilson, Angela R
 Canzian, Federico
 Conde, Lucia
 Cox, David G
 Curtin, Karen
 Foretova, Lenka
 Gapstur, Susan M
 Ghesquières, Hervé
 Glenn, Martha
 Glimelius, Bengt
 Jackson, Rebecca D
 Lan, Qing
 Liebow, Mark
 Maynadie, Marc
 McKay, James
 Melbye, Mads
 Miligi, Lucia
 Milne, Roger L
 Molina, Thierry J
 Morton, Lindsay M
 North, Kari E
 Offit, Kenneth
 Padoan, Marina
 Patel, Alpa V
 Piro, Sara
 Ravichandran, Vignesh
 Riboli, Elio
 de Sanjose, Silvia
 Severson, Richard K
 Southey, Melissa C
 Staines, Anthony
 Stewart, Carolyn
 Travis, Ruth C
 Weiderpass, Elisabete
 Weinstein, Stephanie
 Zheng, Tongzhang
 Chanock, Stephen J
 Chatterjee, Nilanjan
 Rothman, Nathaniel
 Birmann, Brenda M
 Cerhan, James R
 Berndt, Sonja I
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Date
2020-01-28
Date Submitted
Keywords
chronic lymphocytic leukemia
diffuse large B-cell lymphoma
follicular lymphoma
genetics
height
marginal zone lymphoma
non-Hodgkin lymphoma
polygenic risk score
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fonc-09-01539.pdf
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https://hdl.handle.net/10147/629432
Abstract
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
Language
en
Citation
ISSN
2234-943X
eISSN
ISBN
DOI
10.3389/fonc.2019.01539
PMID
32064237
PMCID
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