Radical prostatectomy outcome when performed with PSA above 20 ng/ml.
Connolly, S S Oon, S F Carroll, C Kinsella, S O'Brien, M F Mulvin, D W Quinlan, D M
Connolly, S S
Oon, S F
Carroll, C
Kinsella, S
O'Brien, M F
Mulvin, D W
Quinlan, D M
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Advisors
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Other Contributors
Date
2012-02-01T10:31:36Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Aged
Humans
Male
Middle Aged
Prostate-Specific Antigen/*blood
*Prostatectomy
Prostatic Neoplasms/blood/mortality/*surgery
Survival Rate
Humans
Male
Middle Aged
Prostate-Specific Antigen/*blood
*Prostatectomy
Prostatic Neoplasms/blood/mortality/*surgery
Survival Rate
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
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Abstract
Many centres currently do not offer radical prostatectomy (RP) to men with high-risk localised prostate cancer due to concerns regarding poor outcome, despite evidence to the contrary. We identified 18 men undergoing RP with serum PSA >20 ng/ml (high-risk by National Comprehensive Cancer Network definition) and minimum follow-up of 12 years (mean 13.5). Mean preoperative PSA was 37.0 ng/ml (Range 21.1-94.0). Prostatectomy pathology reported extracapsular disease in 16 (88.9%), positive surgical margins in 15 (83%) and positive pelvic lymph nodes in 5 (27.8%). Overall and cancer-specific survival at 5 and 10-years was 83.3%, 88.2%, 72% and 76.5% respectively. With complete follow-up 11 (61.1%) are alive, and 5 (27.8%) avoided any adjuvant therapy. Complete continence (defined as no involuntary urine leakage and no use of pads) was achieved in 60%, with partial continence in the remainder. We conclude that surgery for this aggressive variant of localised prostate cancer can result in satisfactory outcome.
Language
eng
Citation
ISSN
0332-3102 (Print)
0332-3102 (Linking)
0332-3102 (Linking)
eISSN
ISBN
DOI
PMID
21675092