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MR vs CT imaging: low rectal cancer tumour delineation for three-dimensional conformal radiotherapy.
O'Neill, B D P Salerno, G Thomas, K Tait, D M Brown, G
O'Neill, B D P
Salerno, G
Thomas, K
Tait, D M
Brown, G
Advisors
Editors
Other Contributors
Departments
Date
2009-06
Date Submitted
Keywords
CANCER
RADIOTHERAPY
MAGNETIC RESONANCE IMAGING
COMPUTED TOMOGRAPHY
RADIOTHERAPY
MAGNETIC RESONANCE IMAGING
COMPUTED TOMOGRAPHY
Other Subjects
Subject Mesh
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neoplasm Staging
Prone Position
Prospective Studies
Radiation Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Conformal
Rectal Neoplasms
Supine Position
Tomography, X-Ray Computed
Tumor Burden
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Neoplasm Staging
Prone Position
Prospective Studies
Radiation Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Conformal
Rectal Neoplasms
Supine Position
Tomography, X-Ray Computed
Tumor Burden
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Modern three-dimentional radiotherapy is based upon CT. For rectal cancer, this relies upon target definition on CT, which is not the optimal imaging modality. The major limitation of CT is its low inherent contrast resolution. Targets defined by MRI could facilitate smaller, more accurate, tumour volumes than CT. Our study reviewed imaging and planning data for 10 patients with locally advanced low rectal cancer (defined as < 6 cm from the anal verge on digital examination). Tumour volume and location were compared for sagittal pre-treatment MRI and planning CT. CT consistently overestimated all tumour radiological parameters. Estimates of tumour volume, tumour length and height of proximal tumour from the anal verge were larger on planning CT than on MRI (p < 0.05). Tumour volumes defined on MRI are smaller, shorter and more distal from the anal sphincter than CT-based volumes. For radiotherapy planning, this may result in smaller treatment volumes, which could lead to a reduction in dose to organs at risk and facilitate dose escalation.
Language
en
ISSN
1748-880X
eISSN
ISBN
DOI
10.1259/bjr/60198873
PMID
19153180