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Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
Johnson, Nichola Dudbridge, Frank Orr, Nick Gibson, Lorna Jones, Michael E Schoemaker, Minouk J Folkerd, Elizabeth J Haynes, Ben P Hopper, John L Southey, Melissa C
Johnson, Nichola
Dudbridge, Frank
Orr, Nick
Gibson, Lorna
Jones, Michael E
Schoemaker, Minouk J
Folkerd, Elizabeth J
Haynes, Ben P
Hopper, John L
Southey, Melissa C
Author
Johnson, Nichola
Dudbridge, Frank
Orr, Nick
Gibson, Lorna
Jones, Michael E
Schoemaker, Minouk J
Folkerd, Elizabeth J
Haynes, Ben P
Hopper, John L
Southey, Melissa C
Dite, Gillian S
Apicella, Carmel
Schmidt, Marjanka K
Broeks, Annegien
Van’t Veer, Laura J
Atsma, Femke
Muir, Kenneth
Lophatananon, Artitaya
Fasching, Peter A
Beckmann, Matthias W
Ekici, Arif B
Renner, Stefan P
Sawyer, Elinor
Tomlinson, Ian
Kerin, Michael
Miller, Nicola
Burwinkel, Barbara
Marme, Frederik
Schneeweiss, Andreas
Sohn, Christof
Guénel, Pascal
Truong, Therese
Cordina, Emilie
Menegaux, Florence
Bojesen, Stig E
Nordestgaard, Børge G
Flyger, Henrik
Milne, Roger
Zamora, M P
Arias Perez, Jose I
Benitez, Javier
Bernstein, Leslie
Anton-Culver, Hoda
Ziogas, Argyrios
Clarke Dur, Christina
Brenner, Hermann
Müller, Heiko
Arndt, Volker
Dieffenbach, Aida K
Meindl, Alfons
Heil, Joerg
Bartram, Claus R
Schmutzler, Rita K
Brauch, Hiltrud
Justenhoven, Christina
Ko, Yon-Dschun
The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network
Nevanlinna, Heli
Muranen, Taru A
Aittomäki, Kristiina
Blomqvist, Carl
Matsuo, Keitaro
Dörk, Thilo
Bogdanova, Natalia V
Antonenkova, Natalia N
Lindblom, Annika
Mannermaa, Arto
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M
Chenevix-Trench, Georgia
Beesley, Jonathan
kConFab Investigators
Australian Ovarian Cancer Study Group
Wu, Anna H
Van den Berg, David
Tseng, Chiu-Chen
Lambrechts, Diether
Smeets, Dominiek
Neven, Patrick
Wildiers, Hans
Chang-Claude, Jenny
Rudolph, Anja
Nickels, Stefan
Flesch-Janys, Dieter
Radice, Paolo
Peterlongo, Paolo
Bonanni, Bernardo
Pensotti, Valeria
Couch, Fergus J
Olson, Janet E
Wang, Xianshu
Fredericksen, Zachary
Pankratz, Vernon S
Giles, Graham G
Severi, Gianluca
Baglietto, Laura
Haiman, Chris
Simard, Jacques
Goldberg, Mark S
Labrèche, France
Dumont, Martine
Soucy, Penny
Teo, Soo
Yip, Cheng H
Phuah, Sze Y
Cornes, Belinda K
Kristensen, Vessela N
Grenaker Alnæs, Grethe
Børresen-Dale, Anne-Lise
Zheng, Wei
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Andrulis, Irene L
Knight, Julia A
Glendon, Gord
Mulligan, Anna M
Devillee, Peter
Figueroa, Jonine
Chanock, Stephen J
Lissowska, Jolanta
Sherman, Mark E
Hall, Per
Schoof, Nils
Hooning, Maartje
Hollestelle, Antoinette
Oldenburg, Rogier A
Tilanus-Linthorst, Madeleine
Liu, Jianjun
Cox, Angie
Brock, Ian W
Reed, Malcolm WR
Cross, Simon S
Blot, William
Signorello, Lisa B
Pharoah, Paul DP
Dunning, Alison M
Shah, Mitul
Kang, Daehee
Noh, Dong-Young
Park, Sue K
Choi, Ji-Yeob
Hartman, Mikael
Miao, Hui
Lim, Wei Y
Tang, Anthony
Hamann, Ute
Försti, Asta
Rüdiger, Thomas
Ulmer, Hans U
Jakubowska, Anna
Lubinski, Jan
Jaworska-Bieniek, Katarzyna
Durda, Katarzyna
Sangrajrang, Suleeporn
Gaborieau, Valerie
Brennan, Paul
McKay, James
Slager, Susan
Toland, Amanda E
Vachon, Celine
Yannoukakos, Drakoulis
Shen, Chen-Yang
Yu, Jyh-Cherng
Huang, Chiun-Sheng
Hou, Ming-Feng
González-Neira, Anna
Tessier, Daniel C
Vincent, Daniel
Bacot, Francois
Luccarini, Craig
Dennis, Joe
Michailidou, Kyriaki
Bolla, Manjeet K
Wang, Jean
Easton, Douglas F
García-Closas, Montserrat
Dowsett, Mitch
Ashworth, Alan
Swerdlow, Anthony J
Peto, Julian
dos Santos Silva, Isabel
Fletcher, Olivia
Dudbridge, Frank
Orr, Nick
Gibson, Lorna
Jones, Michael E
Schoemaker, Minouk J
Folkerd, Elizabeth J
Haynes, Ben P
Hopper, John L
Southey, Melissa C
Dite, Gillian S
Apicella, Carmel
Schmidt, Marjanka K
Broeks, Annegien
Van’t Veer, Laura J
Atsma, Femke
Muir, Kenneth
Lophatananon, Artitaya
Fasching, Peter A
Beckmann, Matthias W
Ekici, Arif B
Renner, Stefan P
Sawyer, Elinor
Tomlinson, Ian
Kerin, Michael
Miller, Nicola
Burwinkel, Barbara
Marme, Frederik
Schneeweiss, Andreas
Sohn, Christof
Guénel, Pascal
Truong, Therese
Cordina, Emilie
Menegaux, Florence
Bojesen, Stig E
Nordestgaard, Børge G
Flyger, Henrik
Milne, Roger
Zamora, M P
Arias Perez, Jose I
Benitez, Javier
Bernstein, Leslie
Anton-Culver, Hoda
Ziogas, Argyrios
Clarke Dur, Christina
Brenner, Hermann
Müller, Heiko
Arndt, Volker
Dieffenbach, Aida K
Meindl, Alfons
Heil, Joerg
Bartram, Claus R
Schmutzler, Rita K
Brauch, Hiltrud
Justenhoven, Christina
Ko, Yon-Dschun
The GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network
Nevanlinna, Heli
Muranen, Taru A
Aittomäki, Kristiina
Blomqvist, Carl
Matsuo, Keitaro
Dörk, Thilo
Bogdanova, Natalia V
Antonenkova, Natalia N
Lindblom, Annika
Mannermaa, Arto
Kataja, Vesa
Kosma, Veli-Matti
Hartikainen, Jaana M
Chenevix-Trench, Georgia
Beesley, Jonathan
kConFab Investigators
Australian Ovarian Cancer Study Group
Wu, Anna H
Van den Berg, David
Tseng, Chiu-Chen
Lambrechts, Diether
Smeets, Dominiek
Neven, Patrick
Wildiers, Hans
Chang-Claude, Jenny
Rudolph, Anja
Nickels, Stefan
Flesch-Janys, Dieter
Radice, Paolo
Peterlongo, Paolo
Bonanni, Bernardo
Pensotti, Valeria
Couch, Fergus J
Olson, Janet E
Wang, Xianshu
Fredericksen, Zachary
Pankratz, Vernon S
Giles, Graham G
Severi, Gianluca
Baglietto, Laura
Haiman, Chris
Simard, Jacques
Goldberg, Mark S
Labrèche, France
Dumont, Martine
Soucy, Penny
Teo, Soo
Yip, Cheng H
Phuah, Sze Y
Cornes, Belinda K
Kristensen, Vessela N
Grenaker Alnæs, Grethe
Børresen-Dale, Anne-Lise
Zheng, Wei
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Andrulis, Irene L
Knight, Julia A
Glendon, Gord
Mulligan, Anna M
Devillee, Peter
Figueroa, Jonine
Chanock, Stephen J
Lissowska, Jolanta
Sherman, Mark E
Hall, Per
Schoof, Nils
Hooning, Maartje
Hollestelle, Antoinette
Oldenburg, Rogier A
Tilanus-Linthorst, Madeleine
Liu, Jianjun
Cox, Angie
Brock, Ian W
Reed, Malcolm WR
Cross, Simon S
Blot, William
Signorello, Lisa B
Pharoah, Paul DP
Dunning, Alison M
Shah, Mitul
Kang, Daehee
Noh, Dong-Young
Park, Sue K
Choi, Ji-Yeob
Hartman, Mikael
Miao, Hui
Lim, Wei Y
Tang, Anthony
Hamann, Ute
Försti, Asta
Rüdiger, Thomas
Ulmer, Hans U
Jakubowska, Anna
Lubinski, Jan
Jaworska-Bieniek, Katarzyna
Durda, Katarzyna
Sangrajrang, Suleeporn
Gaborieau, Valerie
Brennan, Paul
McKay, James
Slager, Susan
Toland, Amanda E
Vachon, Celine
Yannoukakos, Drakoulis
Shen, Chen-Yang
Yu, Jyh-Cherng
Huang, Chiun-Sheng
Hou, Ming-Feng
González-Neira, Anna
Tessier, Daniel C
Vincent, Daniel
Bacot, Francois
Luccarini, Craig
Dennis, Joe
Michailidou, Kyriaki
Bolla, Manjeet K
Wang, Jean
Easton, Douglas F
García-Closas, Montserrat
Dowsett, Mitch
Ashworth, Alan
Swerdlow, Anthony J
Peto, Julian
dos Santos Silva, Isabel
Fletcher, Olivia
Advisors
Editors
Other Contributors
Departments
Date
2014-05-26
Date Submitted
Keywords
BREAST CANCER
GENETICS
GENETICS
Other Subjects
Subject Mesh
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Abstract Introduction We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. Methods We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics. Results We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P trend = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P trend = 0.005) but not cases (P trend = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P het = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; P trend = 0.002) but not for those who had their menarche age ≤11 years (ORhet = 1.06, 95% CI 0.95, 1.19, ORhom = 1.07, 95% CI 0.67, 1.72; P trend = 0.29). Conclusions To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.
Language
en