Sweeten, soother and swaddle for retinopathy of prematurity screening: a randomised placebo controlled trial.
O'Sullivan, A O'Connor, M Brosnahan, D McCreery, K Dempsey, E M
O'Sullivan, A
O'Connor, M
Brosnahan, D
McCreery, K
Dempsey, E M
Citations
Altmetric:
Advisors
Editors
Other Contributors
Date
2012-02-01T10:56:57Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Administration, Oral
Analgesia/*methods
Analgesics/administration & dosage
Female
Humans
Infant Care/methods
Infant, Newborn
Infant, Premature
Intensive Care, Neonatal/methods
Male
Neonatal Screening/*adverse effects/methods
*Pacifiers
Pain/etiology/*prevention & control
Pain Measurement/methods
Physical Examination/adverse effects/methods
Prospective Studies
Retinopathy of Prematurity/*diagnosis
Sucrose/administration & dosage
Analgesia/*methods
Analgesics/administration & dosage
Female
Humans
Infant Care/methods
Infant, Newborn
Infant, Premature
Intensive Care, Neonatal/methods
Male
Neonatal Screening/*adverse effects/methods
*Pacifiers
Pain/etiology/*prevention & control
Pain Measurement/methods
Physical Examination/adverse effects/methods
Prospective Studies
Retinopathy of Prematurity/*diagnosis
Sucrose/administration & dosage
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
OBJECTIVE: To assess the efficacy of oral sucrose combined with swaddling and non-nutritive suck (NNS) as a method for reducing pain associated with retinopathy of prematurity (ROP) screening. DESIGN: Randomised placebo controlled study. SETTING: Tertiary level neonatal intensive care unit. SAMPLE: 40 infants undergoing primary eye examination for ROP screening. INTERVENTION: The control group were swaddled, and received 0.2 ml of sterile water given by mouth using a syringe and a soother. The intervention group were swaddled, and received 0.2 ml of sucrose 24% given by mouth using a syringe and a soother. RESULTS: 40 infants were included in the study. There was no difference in mean gestational age at birth, mean birth weight or corrected gestational age at first examination between both groups. The sucrose group had a significantly lower median Neonatal Pain, Agitation and Sedation Scale (N-PASS) score during ROP screening, initially following insertion of the speculum (6.5 vs 5, p=0.02) and subsequently during scleral indentation (9.5 vs 7.5, p=0.03). Fewer infants experienced episodes of desaturations or bradycardia in the intervention group (1 vs 4, p=0.18). CONCLUSION: ROP screening is a necessary but recognised painful procedure. Sucrose combined with NNS and swaddling reduced the behavioural and physiological pain responses. However, pain scores remained consistently high and appropriate pain relief for ROP screening remains a challenge.
Language
eng
ISSN
1468-2052 (Electronic)
1359-2998 (Linking)
1359-2998 (Linking)
eISSN
ISBN
DOI
10.1136/adc.2009.180943
PMID
20876596