Felbamate in an adult population with severe refractory epilepsy.
Kearney, H Delanty, N
Kearney, H
Delanty, N
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Date
2011-04-05T11:15:56Z
Date Submitted
Keywords
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Subject Mesh
Adult
Anticonvulsants
Epilepsy
Female
Humans
Ireland
Male
Middle Aged
Phenylcarbamates
Propylene Glycols
Retrospective Studies
Treatment Outcome
Anticonvulsants
Epilepsy
Female
Humans
Ireland
Male
Middle Aged
Phenylcarbamates
Propylene Glycols
Retrospective Studies
Treatment Outcome
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Felbamate (FBM) is efficacious in treating patients with refractory epilepsy but was withdrawn due to cases of aplastic anaemia, hepatic failure and five reported deaths. FBM is currently used in specialist centres and is only being used in one Irish centre to date. This papers aim is to review the efficacy and safety experience of FBM in Irish adult patients with refractory epilepsy. A retrospective chart review was done on patients' medical records. Patients were subdivided into responders and non responders based on change in seizure frequency and side effects were recorded for all. Of the 13 patients on FBM nine patients responded to FBM, four patients did not. FBM is a safe and efficacious alternative in an Irish adult population with refractory epilepsy. However close monitoring is still required given the potential fatal side effects that are possible with this anticonvulsant.
Language
en
ISSN
0332-3102
eISSN
ISBN
DOI
PMID
20108801