Oncogenic impact of human papilloma virus in head and neck cancer.
Heffernan, C B O'Neill, J P Timon, C
Heffernan, C B
O'Neill, J P
Timon, C
Author
Advisors
Editors
Other Contributors
Date
2012-02-01T10:40:17Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adolescent
Adult
Carcinoma, Squamous Cell/epidemiology/*virology
Child
Female
*Human papillomavirus 16/genetics/immunology
*Human papillomavirus 18/genetics/immunology
Humans
Male
Mucous Membrane/virology
Oropharyngeal Neoplasms/epidemiology/*virology
Papillomavirus Infections/complications/epidemiology/*prevention & control
*Papillomavirus Vaccines/immunology
Prevalence
Risk Factors
Sexual Behavior
Sexually Transmitted Diseases, Viral/complications/epidemiology
Uterine Cervical Neoplasms/prevention & control/virology
Adult
Carcinoma, Squamous Cell/epidemiology/*virology
Child
Female
*Human papillomavirus 16/genetics/immunology
*Human papillomavirus 18/genetics/immunology
Humans
Male
Mucous Membrane/virology
Oropharyngeal Neoplasms/epidemiology/*virology
Papillomavirus Infections/complications/epidemiology/*prevention & control
*Papillomavirus Vaccines/immunology
Prevalence
Risk Factors
Sexual Behavior
Sexually Transmitted Diseases, Viral/complications/epidemiology
Uterine Cervical Neoplasms/prevention & control/virology
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
There is considerable debate within the literature about the significance of human papilloma virus in head and neck squamous cell carcinoma, and its potential influence on the prevention, diagnosis, grading, treatment and prognosis of these cancers. Cigarette smoking and alcohol consumption have traditionally been cited as the main risk factors for head and neck cancers. However, human papilloma virus, normally associated with cervical and other genital carcinomas, has emerged as a possible key aetiological factor in head and neck squamous cell carcinoma, especially oropharyngeal cancers. These cancers pose a significant financial burden on health resources and are increasing in incidence. The recent introduction of vaccines targeted against human papilloma virus types 16 and 18, to prevent cervical cancer, has highlighted the need for ongoing research into the importance of human papilloma virus in head and neck squamous cell carcinoma.
Language
eng
ISSN
1748-5460 (Electronic)
0022-2151 (Linking)
0022-2151 (Linking)
eISSN
ISBN
DOI
10.1017/S0022215110001179
PMID
20519038