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Neutrophils: Need for Standardized Nomenclature.
McKenna, Ellen Mhaonaigh, Aisling Ui Wubben, Richard Dwivedi, Amrita Hurley, Tim Kelly, Lynne A Stevenson, Nigel J Little, Mark A Molloy, Eleanor J
McKenna, Ellen
Mhaonaigh, Aisling Ui
Wubben, Richard
Dwivedi, Amrita
Hurley, Tim
Kelly, Lynne A
Stevenson, Nigel J
Little, Mark A
Molloy, Eleanor J
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Date
2021-04-15
Date Submitted
Keywords
granulopoiesis
low density neutrophils
neutrophil granules
neutrophils
nomenclature
low density neutrophils
neutrophil granules
neutrophils
nomenclature
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fimmu-12-602963.pdf
Adobe PDF, 1.59 MB
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Abstract
Neutrophils are the most abundant innate immune cell with critical anti-microbial functions. Since the discovery of granulocytes at the end of the nineteenth century, the cells have been given many names including phagocytes, polymorphonuclear neutrophils (PMN), granulocytic myeloid derived suppressor cells (G-MDSC), low density neutrophils (LDN) and tumor associated neutrophils (TANS). This lack of standardized nomenclature for neutrophils suggest that biologically distinct populations of neutrophils exist, particularly in disease, when in fact these may simply be a manifestation of the plasticity of the neutrophil as opposed to unique populations. In this review, we profile the surface markers and granule expression of each stage of granulopoiesis to offer insight into how each stage of maturity may be identified. We also highlight the remarkable surface marker expression profiles between the supposed neutrophil populations.
Language
en
Citation
ISSN
eISSN
1664-3224
ISBN
DOI
10.3389/fimmu.2021.602963
PMID
33936029