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Microbial epidemiology and clinical risk factors of carbapenemase-producing Enterobacterales amongst Irish patients from first detection in 2009 until 2020.
O'Connell, N H Gasior, S Slevin, B Power, L Barrett, S Bhutta, S I Minihan, B Powell, J
O'Connell, N H
Gasior, S
Slevin, B
Power, L
Barrett, S
Bhutta, S I
Minihan, B
Powell, J
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Date
2022-07-13
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Keywords
CPE Risk factors epidemiology clinical outcomes
MICROBIOLOGY
CARBAPENEMASE PRODUCING ENTEROBACTERALES (CPE)
ACUTE HOSPITALS
MICROBIOLOGY
CARBAPENEMASE PRODUCING ENTEROBACTERALES (CPE)
ACUTE HOSPITALS
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Abstract
Among CPE strains isolated from 460 patients, Klebsiella pneumoniae carbapenemase (KPC) was the carbapenemase most frequently detected, accounting for 87.4% (459) of all CPE enzymes. Citrobacter species 177 (33.7%) were the most common species harbouring this enzyme. 428 CPE positive patients (93%) were identified in the acute hospital setting; the most common risk factor for CPE acquisition was history of hospitalisation, observed in 305 (66%) cases. Thirty patients (6.5%) had confirmed infections post-acquisition, of which four were bloodstream infections. There were 19 subsequent episodes of non CPE-related bacteraemia in this cohort. All causal mortality at 30 days was 41 patients (8.9%). However, clinical review determined that CPE was an indirect associative factor in 8 patient deaths.
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en
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eISSN
2590-0889
ISBN
DOI
10.1016/j.infpip.2022.100230
PMID
35935263