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Pulmonary aspiration in preschool children with cystic fibrosis.
Clarke, D Gorman, I Ringholz, F McDermott, M Cox, D W Greally, P Linnane, B Mc Nally, P
Clarke, D
Gorman, I
Ringholz, F
McDermott, M
Cox, D W
Greally, P
Linnane, B
Mc Nally, P
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Date
2018-12-17
Date Submitted
Keywords
CYSTIC FIBROSIS
CHILDREN
CHILDREN
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Adobe PDF, 485.99 KB
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Abstract
Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Elevated pepsin levels were found in a subgroup of children with CF, but this was not found to be associated with pulmonary infection, pulmonary inflammation or respiratory or gastrointestinal symptoms.
Language
en
Citation
ISSN
1465-993X
eISSN
ISBN
DOI
10.1186/s12931-018-0954-1
PMID
30558606