Loading...
Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS).
Roberts, Jackson A Varma, Vijay R Huang, Chiung-Wei An, Yang Oommen, Anup Tanaka, Toshiko Ferrucci, Luigi Elango, Palchamy Takebayashi, Toru Harada, Sei
Roberts, Jackson A
Varma, Vijay R
Huang, Chiung-Wei
An, Yang
Oommen, Anup
Tanaka, Toshiko
Ferrucci, Luigi
Elango, Palchamy
Takebayashi, Toru
Harada, Sei
Advisors
Editors
Other Contributors
Departments
Date
2020-02-13
Date Submitted
Keywords
amino acids
blood pressure
fasting glucose
metabolic syndrome
metabolomics
triglycerides
Waist circumference
blood pressure
fasting glucose
metabolic syndrome
metabolomics
triglycerides
Waist circumference
Other Subjects
Subject Mesh
Planned Date
Start Date
Collaborators
Principal Investigators
Files
Loading...
ijms-21-01249-v2.pdf
Adobe PDF, 4.11 MB
Alternative Titles
Publisher
Abstract
Rapid lifestyle and dietary changes have contributed to a rise in the global prevalence of metabolic syndrome (MetS), which presents a potential healthcare crisis, owing to its association with an increased burden of multiple cardiovascular and neurological diseases. Prior work has identified the role that genetic, lifestyle, and environmental factors can play in the prevalence of MetS. Metabolomics is an important tool to study alterations in biochemical pathways intrinsic to the pathophysiology of MetS. We undertook a metabolomic study of MetS in serum samples from two ethnically distinct, well-characterized cohorts-the Baltimore Longitudinal Study of Aging (BLSA) from the U.S. and the Tsuruoka Metabolomics Cohort Study (TMCS) from Japan. We used multivariate logistic regression to identify metabolites that were associated with MetS in both cohorts. Among the top 25 most significant (lowest p-value) metabolite associations with MetS in each cohort, we identified 18 metabolites that were shared between TMCS and BLSA, the majority of which were classified as amino acids. These associations implicate multiple biochemical pathways in MetS, including branched-chain amino acid metabolism, glutathione production, aromatic amino acid metabolism, gluconeogenesis, and the tricarboxylic acid cycle. Our results suggest that fundamental alterations in amino acid metabolism may be central features of MetS.
Language
en
Citation
ISSN
eISSN
1422-0067
ISBN
DOI
10.3390/ijms21041249
PMID
32070008