Hypoglycaemia-induced myocardial infarction as a result of sulphonylurea misuse.
Corley, B T Davenport, C Delaney, L Hatunic, M Smith, D
Corley, B T
Davenport, C
Delaney, L
Hatunic, M
Smith, D
Advisors
Editors
Other Contributors
Date
2012-02-01T10:01:21Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Aged
Diabetes Mellitus, Type 2/chemically induced/complications/*physiopathology
Diabetic Angiopathies/chemically induced/etiology/*physiopathology
Female
Humans
Hypoglycemia/chemically induced/complications/*physiopathology
Myocardial Infarction/chemically induced/etiology/*physiopathology
Sulfonylurea Compounds/administration & dosage/*adverse effects
Treatment Outcome
Diabetes Mellitus, Type 2/chemically induced/complications/*physiopathology
Diabetic Angiopathies/chemically induced/etiology/*physiopathology
Female
Humans
Hypoglycemia/chemically induced/complications/*physiopathology
Myocardial Infarction/chemically induced/etiology/*physiopathology
Sulfonylurea Compounds/administration & dosage/*adverse effects
Treatment Outcome
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
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Abstract
BACKGROUND: Recent large-scale randomized trials of intensive therapy in Type 2 diabetes have reported increased cardiovascular morbidity and mortality in patient populations who experience a high frequency of hypoglycaemic events. However, there are few descriptions of hypoglycaemia leading directly to a myocardial infarction (MI) in the medical literature to date. CASE REPORT: In this article we describe the case of a 76-year-old woman without diabetes who presented with symptoms, left bundle branch block and raised troponin, indicative of an MI. She was also noted to be hypoglycaemic with a plasma glucose level of 2.5 mmol/l. It was subsequently discovered that she had mistakenly been dispensed glibenclamide, a long-acting sulphonylurea, in the preceding weeks. Her cardiac symptoms resolved completely upon treatment of her hypoglycaemia and she had no significant coronary artery disease on angiography. CONCLUSION: This is the first case of sulphonylurea-induced MI in a patient without diabetes and illustrates the adverse effects of acute hypoglycaemia upon the cardiovascular system.
Language
eng
ISSN
1464-5491 (Electronic)
0742-3071 (Linking)
0742-3071 (Linking)
eISSN
ISBN
DOI
10.1111/j.1464-5491.2010.03226.x
PMID
21204965