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Microbial and viral pathogens in colorectal cancer.
Collins, Danielle Hogan, Aisling M Winter, Desmond C
Collins, Danielle
Hogan, Aisling M
Winter, Desmond C
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Date
2012-02-01T10:29:05Z
Date Submitted
Keywords
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Subject Mesh
Alphapapillomavirus
Bacterial Infections/*complications/metabolism/microbiology/physiopathology
Bacterial Toxins/*adverse effects
Bacteroides
Cell Transformation, Neoplastic/chemically induced/*metabolism
Colorectal Neoplasms/*microbiology/physiopathology/*virology
Cyclooxygenase 2/metabolism
Cytomegalovirus
DNA Damage
Escherichia coli
Free Radicals/metabolism
Helicobacter pylori
Herpesvirus 4, Human
Humans
Inflammation/*metabolism/physiopathology
JC Virus
NF-kappa B/metabolism
Neovascularization, Pathologic/*metabolism/physiopathology
Streptococcus bovis
Virus Diseases/*complications/metabolism/physiopathology/virology
Bacterial Infections/*complications/metabolism/microbiology/physiopathology
Bacterial Toxins/*adverse effects
Bacteroides
Cell Transformation, Neoplastic/chemically induced/*metabolism
Colorectal Neoplasms/*microbiology/physiopathology/*virology
Cyclooxygenase 2/metabolism
Cytomegalovirus
DNA Damage
Escherichia coli
Free Radicals/metabolism
Helicobacter pylori
Herpesvirus 4, Human
Humans
Inflammation/*metabolism/physiopathology
JC Virus
NF-kappa B/metabolism
Neovascularization, Pathologic/*metabolism/physiopathology
Streptococcus bovis
Virus Diseases/*complications/metabolism/physiopathology/virology
Planned Date
Start Date
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Abstract
The heterogenetic and sporadic nature of colorectal cancer has led to many epidemiological associations with causes of this disease. As our understanding of the underlying molecular processes in colorectal-cancer develops, the concept of microbial-epithelial interactions as an oncogenic trigger might provide a plausible hypothesis for the pathogenesis of colorectal cancer. By contrast with other cancers of the gastrointestinal tract (gastric carcinoma, mucosa-associated lymphoid-tissue lymphoma), a direct causal link between microbial infection (bacteria and viruses) and colorectal carcinoma has not been established. Studies support the involvement of these organisms in oncogenesis, however, in colorectal cancer, clinical data are lacking. Here, we discuss current evidence (both in vitro and clinical studies), and focus on a putative role for bacterial and viral pathogens as a cause of colorectal cancer.
Language
eng
ISSN
1474-5488 (Electronic)
1470-2045 (Linking)
1470-2045 (Linking)
eISSN
ISBN
DOI
10.1016/S1470-2045(10)70186-8
PMID
21067973