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Endoscopic ultrasound with fine needle aspiration and biopsy in lung cancer and isolated mediastinal lymphadenopathy.
Nadarajan, P Sulaiman, I Kent, B Breslin, N Moloney, E D Lane, S J
Nadarajan, P
Sulaiman, I
Kent, B
Breslin, N
Moloney, E D
Lane, S J
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Editors
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Departments
Date
2010-03
Date Submitted
Keywords
Other Subjects
Subject Mesh
Aged
Aged, 80 and over
Biopsy, Fine-Needle
Bronchoscopy
Endosonography
Female
Humans
Lung Neoplasms
Lymphatic Diseases
Male
Mediastinal Diseases
Mediastinoscopy
Middle Aged
Neoplasm Staging
Prospective Studies
Sensitivity and Specificity
Tomography, X-Ray Computed
Aged, 80 and over
Biopsy, Fine-Needle
Bronchoscopy
Endosonography
Female
Humans
Lung Neoplasms
Lymphatic Diseases
Male
Mediastinal Diseases
Mediastinoscopy
Middle Aged
Neoplasm Staging
Prospective Studies
Sensitivity and Specificity
Tomography, X-Ray Computed
Planned Date
Start Date
Collaborators
Principal Investigators
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Article5452.pdf
Adobe PDF, 9.47 KB
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Abstract
Endoscopic ultrasound with fine-needle aspiration and biopsy (EUS-FNAB) is well established in diagnosing and staging lung cancer in patients with mediastinal adenopathy. EUS-FNAB is highly sensitive, less invasive and has lower complication rates when compared to surgical staging of mediastinal nodes. In this study we describe our experience of EUS-FNAB in lung cancer and other causes of mediastinal lymphadenopathy. EUS-FNAB was performed for assessment of PET positive mediastinal lymph nodes between January 2007 and March 2009 in AMNCH. The endpoints of our study were sensitivity and specificity of EUS-FNAB, morbidity and length of hospital stay. Thirty four patients underwent EUS-FNAB during the study period for both diagnosis and staging. Thirty patients had positive lymph node invasion and 4 had no evidence of malignant invasion. In these 4 patients negative cytology was confirmed on mediastinoscopy giving EUS-FNAB a sensitivity and specificity of 100%. EUS-FNAB upstaged the disease in 12 patients. EUS-FNAB is a reliable tool for mediastinal staging in lung cancer, significantly reducing the need for surgical staging procedures in patients with suspected mediastinal involvement.
Language
en
ISSN
0332-3102
eISSN
ISBN
DOI
PMID
20666069