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Leptin, Adiponectin, and Melatonin Modulate Colostrum Lymphocytes in Mothers with Obesity.
Pereira, Gabrielle do Amaral Virginio França, Eduardo Luzia Daboin, Blanca Elena Guerrero de Quental, Ocilma Barros
Pereira, Gabrielle do Amaral Virginio
França, Eduardo Luzia
Daboin, Blanca Elena Guerrero
de Quental, Ocilma Barros
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Date
2023-01-31
Date Submitted
Keywords
adiponectin
breast milk
Hormones
leptin
Lymphocytes
OBESITY
colostrum
melatonin
melatonin
breast milk
Hormones
leptin
Lymphocytes
OBESITY
colostrum
melatonin
melatonin
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ijms-24-02662.pdf
Adobe PDF, 1.91 MB
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Abstract
Pregnancy complicated by obesity is associated with adverse triggered gestational and neonatal outcomes, with reductions in the subtypes of CD4+ T-lymphocytes representing the modulators of inflammation. It needs to be better established how maternal nutritional statuses impact the neuroendocrine-immune system's action and affect the immunological mechanisms of the maternal-infant relationship via breastfeeding. This study examined the effects of maternal obesity on human colostrum lymphocytes and the intracellular mechanisms of lymphocyte modulation in the presence of leptin, adiponectin, and melatonin via cell proliferation; the release of intracellular calcium; and apoptosis induction. This cross-sectional study analyzed colostrum samples from 52 puerperal splits and divided them into overweight and eutrophic groups. Colostrum lymphocytes underwent immunophenotyping and cell proliferation by flow cytometry and intracellular calcium release and apoptosis assays by immunofluorescence in the presence or absence of hormones. Significant differences were considered when p < 0.05 by the chi-square or t-test. Maternal obesity reduced the population of T-lymphocytes and TCD4+ in human colostrum and proliferative activities (p < 0.05). These hormones restore lymphocyte proliferation to a level similar to the eutrophic group (p < 0.05). Leptin, adiponectin, melatonin hormones, and biological actions consolidated in the scientific literature also represent maternal and infant protection mechanisms via colostrum and the modulation of human colostrum lymphocytes.
Language
en
Citation
ISSN
eISSN
1422-0067
ISBN
DOI
10.3390/ijms24032662
PMID
36768983
PMCID
PMC9917098