Publication

Perioperative plasma concentrations of stable nitric oxide products are predictive of cognitive dysfunction after laparoscopic cholecystectomy.

Iohom, G
; 
Szarvas, S
; 
Larney, V
; 
O'Brien, J
; 
Buckley, E
; 
Butler, M
; 
Shorten, G
Author
Iohom, G
 Szarvas, S
 Larney, V
 O'Brien, J
 Buckley, E
 Butler, M
 Shorten, G
Advisors
Editors
Other Contributors
Departments
Department of Anesthesia and Intensive Care Medicine, Cork University Hospital,, Cork, Ireland.
Date
2012-02-03T15:08:09Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Affect
Aged
Aged, 80 and over
Algorithms
Anesthesia, Inhalation
Anesthetics, Inhalation
Biological Markers
Cholecystectomy, Laparoscopic/*adverse effects
Cognition Disorders/diagnosis/*etiology/*psychology
Depression/psychology
Female
Humans
Male
Memory/drug effects
Methyl Ethers
Middle Aged
Nerve Growth Factors
Neuropsychological Tests
Nitric Oxide/*blood
Postoperative Complications/*etiology/*psychology
Predictive Value of Tests
Psychiatric Status Rating Scales
Psychomotor Performance/drug effects
S100 Proteins/blood
Speech/drug effects
Vasodilator Agents/*blood
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
URI
https://hdl.handle.net/10147/208946
Abstract
In this study our objectives were to determine the incidence of postoperative cognitive dysfunction (POCD) after laparoscopic cholecystectomy under sevoflurane anesthesia in patients aged >40 and <85 yr and to examine the associations between plasma concentrations of i) S-100beta protein and ii) stable nitric oxide (NO) products and POCD in this clinical setting. Neuropsychological tests were performed on 42 ASA physical status I-II patients the day before, and 4 days and 6 wk after surgery. Patient spouses (n = 13) were studied as controls. Cognitive dysfunction was defined as deficit in one or more cognitive domain(s). Serial measurements of serum concentrations of S-100beta protein and plasma concentrations of stable NO products (nitrate/nitrite, NOx) were performed perioperatively. Four days after surgery, new cognitive deficit was present in 16 (40%) patients and in 1 (7%) control subject (P = 0.01). Six weeks postoperatively, new cognitive deficit was present in 21 (53%) patients and 3 (23%) control subjects (P = 0.03). Compared with the "no deficit" group, patients who demonstrated a new cognitive deficit 4 days postoperatively had larger plasma NOx at each perioperative time point (P < 0.05 for each time point). Serum S-100beta protein concentrations were similar in the 2 groups. In conclusion, preoperative (and postoperative) plasma concentrations of stable NO products (but not S-100beta) are associated with early POCD. The former represents a potential biochemical predictor of POCD.
Language
eng
Citation
Anesth Analg. 2004 Oct;99(4):1245-52, table of contents.
ISSN
0003-2999 (Print)
0003-2999 (Linking)
eISSN
ISBN
DOI
10.1213/01.ANE.0000132971.00206.4A
PMID
15385384
PMCID
Sponsorships
Funding Sources
Funding Amounts
Grant Identifiers
Methodology
Duration
Ethical Approval