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Changes in Invasive Pneumococcal Disease Caused by Serotype 1 Following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project.

Health Protection Surveillance Centre
; 
Bennett, Julia C
; 
Hetrich, Marissa K
; 
Garcia Quesada, Maria
; 
Sinkevitch, Jenna N
; 
Deloria Knoll, Maria
; 
Feikin, Daniel R
; 
Zeger, Scott L
; 
Kagucia, Eunice W
; 
Cohen, Adam L
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Author
Health Protection Surveillance Centre
 Bennett, Julia C
 Hetrich, Marissa K
 Garcia Quesada, Maria
 Sinkevitch, Jenna N
 Deloria Knoll, Maria
 Feikin, Daniel R
 Zeger, Scott L
 Kagucia, Eunice W
 Cohen, Adam L
 Ampofo, Krow
 Brandileone, Maria-Cristina C
 Bruden, Dana
 Camilli, Romina
 Castilla, Jesús
 Chan, Guanhao
 Cook, Heather
 Cornick, Jennifer E
 Dagan, Ron
 Dalby, Tine
 Danis, Kostas
 de Miguel, Sara
 De Wals, Philippe
 Desmet, Stefanie
 Georgakopoulou, Theano
 Gilkison, Charlotte
 Grgic-Vitek, Marta
 Hammitt, Laura L
 Hilty, Markus
 Ho, Pak-Leung
 Jayasinghe, Sanjay
 Kellner, James D
 Kleynhans, Jackie
 Knol, Mirjam J
 Kozakova, Jana
 Kristinsson, Karl G
 Ladhani, Shamez N
 MacDonald, Laura
 Mackenzie, Grant A
 Mad'arová, Lucia
 McGeer, Allison
 Mereckiene, Jolita
 Morfeldt, Eva
 Mungun, Tuya
 Muñoz-Almagro, Carmen
 Nuorti, J Pekka
 Paragi, Metka
 Pilishvili, Tamara
 Puentes, Rodrigo
 Saha, Samir K
 Sahu Khan, Aalisha
 Savrasova, Larisa
 Scott, J Anthony
 Skoczyńska, Anna
 Suga, Shigeru
 van der Linden, Mark
 Verani, Jennifer R
 von Gottberg, Anne
 Winje, Brita A
 Yildirim, Inci
 Zerouali, Khalid
 Hayford, Kyla
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Date
27/03/2021
Date Submitted
Keywords
CORONAVIRUS
COVID-19
INFECTION PREVENTION AND CONTROL
invasive pneumococcal disease
pneumococcal conjugate vaccines
serotypes
vaccine impact
Other Subjects
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Start Date
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microorganisms-09-00696-v4.pdf
Adobe PDF, 1.73 MB
Alternative Titles
Publisher
Health Service Executive
URI
https://hdl.handle.net/10147/631727
Abstract
Streptococcus pneumoniae serotype 1 (ST1) was an important cause of invasive pneumococcal disease (IPD) globally before the introduction of pneumococcal conjugate vaccines (PCVs) containing ST1 antigen. The Pneumococcal Serotype Replacement and Distribution Estimation (PSERENADE) project gathered ST1 IPD surveillance data from sites globally and aimed to estimate PCV10/13 impact on ST1 IPD incidence. We estimated ST1 IPD incidence rate ratios (IRRs) comparing the pre-PCV10/13 period to each post-PCV10/13 year by site using a Bayesian multi-level, mixed-effects Poisson regression and all-site IRRs using a linear mixed-effects regression (N = 45 sites). Following PCV10/13 introduction, the incidence rate (IR) of ST1 IPD declined among all ages. After six years of PCV10/13 use, the all-site IRR was 0.05 (95% credibility interval 0.04-0.06) for all ages, 0.05 (0.04-0.05) for <5 years of age, 0.08 (0.06-0.09) for 5-17 years, 0.06 (0.05-0.08) for 18-49 years, 0.06 (0.05-0.07) for 50-64 years, and 0.05 (0.04-0.06) for ≥65 years. PCV10/13 use in infant immunization programs was followed by a 95% reduction in ST1 IPD in all ages after approximately 6 years. Limited data availability from the highest ST1 disease burden countries using a 3+0 schedule constrains generalizability and data from these settings are needed.
Language
en
Citation
ISSN
2076-2607
eISSN
ISBN
DOI
10.3390/microorganisms9040696
PMID
33801760
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