Publication

Trends in antimicrobial susceptibility among isolates of Campylobacter species in Ireland and the emergence of resistance to ciprofloxacin.

Lucey, B
; 
Cryan, B
; 
O'Halloran, F
; 
Wall, P G
; 
Buckley, T
; 
Fanning, S
Author
Lucey, B
 Cryan, B
 O'Halloran, F
 Wall, P G
 Buckley, T
 Fanning, S
Advisors
Editors
Other Contributors
Departments
Department of Medical Microbiology, Cork University Hospital, Wilton, Ireland.
Date
2012-02-03T15:10:06Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Animals
Anti-Infective Agents/*pharmacology
Campylobacter coli/*drug effects/isolation & purification
Campylobacter jejuni/*drug effects/genetics/isolation & purification
Ciprofloxacin/*pharmacology
Drug Resistance/genetics
Humans
Polymerase Chain Reaction
Poultry
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
URI
https://hdl.handle.net/10147/209020
Abstract
Measurements were made of the susceptibility to six commonly prescribed antibiotics, including erythromycin, tetracycline and ciprofloxacin, of 130 isolates of Campylobacterjejuni and 15 isolates of Campylobacter coli cultured from human and poultry sources during 2000. The results were compared with the results from a collection of strains isolated between 1996 and 1998. The levels of resistance to erythromycin remained low, 2 per cent and 4.4 per cent for the human and poultry isolates, respectively. Resistance to tetracycline had increased to 31 per cent and 24.4 per cent from 13.9 per cent and 18.8 per cent for the human and poultry isolates, respectively. However, the resistance to ciprofloxacin of the strains isolated during 2000 had increased to 30 per cent, whereas between 1996 and 1998 there had been no resistance to this agent among human isolates, and only 3.1 per cent resistance among poultry isolates. The molecular basis for this resistance has been shown to be the result of a single amino acid substitution, Thr-86-Ile, in the gyrA subunit of DNA gyrase in Cjejuni. A subset of 59 isolates was tested by molecular methods and all of the 25 phenotypically resistant isolates possessed this substitution. None of the human isolates had been treated with ciprofloxacin before their laboratory isolation.
Language
eng
Citation
Vet Rec. 2002 Sep 14;151(11):317-20.
ISSN
0042-4900 (Print)
0042-4900 (Linking)
eISSN
ISBN
DOI
PMID
12356234
PMCID
Sponsorships
Funding Sources
Funding Amounts
Grant Identifiers
Methodology
Duration
Ethical Approval