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Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent infection.
Mullish, Benjamin H McDonald, Julie A K Pechlivanis, Alexandros Allegretti, Jessica R Kao, Dina Barker, Grace F Kapila, Diya Petrof, Elaine O Joyce, Susan A Gahan, Cormac G M
Mullish, Benjamin H
McDonald, Julie A K
Pechlivanis, Alexandros
Allegretti, Jessica R
Kao, Dina
Barker, Grace F
Kapila, Diya
Petrof, Elaine O
Joyce, Susan A
Gahan, Cormac G M
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Date
11/02/2019
Date Submitted
Keywords
bile acids
bile salt hydrolase
clostridioides difficile
gut microbiota
metabonome
FAECAL MACROBIOTA TRANSPLANTATION
bile salt hydrolase
clostridioides difficile
gut microbiota
metabonome
FAECAL MACROBIOTA TRANSPLANTATION
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1791.full.pdf
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Abstract
Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile salt hydrolases (BSHs) predisposes to CDI by perturbing gut bile metabolism, and that BSH restitution is a key mediator of FMT's efficacy in treating the condition.
Language
en
Citation
ISSN
eISSN
1468-3288
ISBN
DOI
10.1136/gutjnl-2018-317842
PMID
30816855