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Leucocyte esterase in the rapid diagnosis of paediatric septic arthritis.
Kelly, E G Cashman, J P
Kelly, E G
Cashman, J P
Author
Advisors
Editors
Other Contributors
Date
2013-02
Date Submitted
Keywords
Other Subjects
Subject Mesh
Arthritis, Infectious
Carboxylic Ester Hydrolases
Child
Humans
Models, Biological
Synovial Fluid
Time Factors
Carboxylic Ester Hydrolases
Child
Humans
Models, Biological
Synovial Fluid
Time Factors
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Septic arthritis may affect any age group but is more common in the paediatric population. Infection is generally bacterial in nature. Prompt diagnosis is crucial, as delayed treatment is associated with lifelong joint dysfunction. A clinical history and application of Kocher's criteria may indicate that there is a septic arthritis. However, definitive diagnosis is made on culture of septic synovial fluid. The culture process can take over 24h for the initial culture to yield bacterial colonies. Leucocyte esterase is released by leucocytes at the site of an infection. We hypothesise that leucocyte esterase can be utilized in the rapid diagnosis of septic arthritis and shorten the time to decisive treatment whilst simultaneously decreasing unnecessary treatment of non-septic joints.
Language
en
ISSN
1532-2777
eISSN
ISBN
DOI
10.1016/j.mehy.2012.11.026
PMID
23257651