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Clozapine-induced severe mixed hyperlipidemia: a case report.
Ahmed, Mohamed Griffin, Damian O'Toole, Ray McDonald, Colm
Ahmed, Mohamed
Griffin, Damian
O'Toole, Ray
McDonald, Colm
Advisors
Editors
Other Contributors
Date
2009-01
Date Submitted
Keywords
Other Subjects
Subject Mesh
Antipsychotic Agents
Cholesterol
Clozapine
Humans
Hyperlipidemias
Ireland
Male
Middle Aged
Schizophrenia
Severity of Illness Index
Triglycerides
Cholesterol
Clozapine
Humans
Hyperlipidemias
Ireland
Male
Middle Aged
Schizophrenia
Severity of Illness Index
Triglycerides
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
To highlight the association between the use of clozapine and the early development of severe mixed hyperlipidemia, a condition that substantially increases the risk of cardiovascular events and other medical complications.
Clinical information and data from investigations in a single patient were collated and reviewed in light of the literature.
A 47-year-old man with a background history of schizophrenia taking clozapine presented with multiple episodes of severe elevation of serum triglycerides and cholesterol with subsequent development of diabetes mellitus. His metabolic parameters normalized following discontinuation of clozapine.
Lipid and metabolic profiles should be closely monitored in patients receiving clozapine in order to facilitate early detection and intervention to prevent further health complications.
Clinical information and data from investigations in a single patient were collated and reviewed in light of the literature.
A 47-year-old man with a background history of schizophrenia taking clozapine presented with multiple episodes of severe elevation of serum triglycerides and cholesterol with subsequent development of diabetes mellitus. His metabolic parameters normalized following discontinuation of clozapine.
Lipid and metabolic profiles should be closely monitored in patients receiving clozapine in order to facilitate early detection and intervention to prevent further health complications.
Language
en
ISSN
1873-7714
eISSN
ISBN
DOI
10.1016/j.genhosppsych.2008.07.003
PMID
19134516