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Occupation and risk of upper aerodigestive tract cancer: the ARCAGE study.

Richiardi, Lorenzo
; 
Corbin, Marine
; 
Marron, Manuela
; 
Ahrens, Wolfgang
; 
Pohlabeln, Hermann
; 
Lagiou, Pagona
; 
Minaki, Ploumitsa
; 
Agudo, Antonio
; 
Castellsague, Xavier
; 
Slamova, Alena
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Author
Richiardi, Lorenzo
 Corbin, Marine
 Marron, Manuela
 Ahrens, Wolfgang
 Pohlabeln, Hermann
 Lagiou, Pagona
 Minaki, Ploumitsa
 Agudo, Antonio
 Castellsague, Xavier
 Slamova, Alena
 Schejbalova, Miriam
 Kjaerheim, Kristina
 Barzan, Luigi
 Talamini, Renato
 Macfarlane, Gary J
 Macfarlane, Tatiana V
 Canova, Cristina
 Simonato, Lorenzo
 Conway, David I
 McKinney, Patricia A
 Sneddon, Linda
 Thomson, Peter
 Znaor, Ariana
 Healy, Claire M
 McCartan, Bernard E
 Benhamou, Simone
 Bouchardy, Christine
 Hashibe, Mia
 Brennan, Paul
 Merletti, Franco
Advisors
Editors
Other Contributors
Departments
University of Turin, Turin, Italy. lorenzo.richiardi@unito.it
Date
2012-05-15
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Aged
Case-Control Studies
Construction Industry
Esophageal Neoplasms
Europe
Female
Humans
Laryngeal Neoplasms
Male
Middle Aged
Mouth Neoplasms
Neoplasms
Occupations
Pharyngeal Neoplasms
Risk
Risk Factors
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
URI
https://hdl.handle.net/10147/291060
Abstract
We investigated the association between occupational history and upper aerodigestive tract (UADT) cancer risk in the ARCAGE European case-control study. The study included 1,851 patients with incident cancer of the oral cavity, oropharynx, hypopharynx, larynx or esophagus and 1,949 controls. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ever employment in 283 occupations and 172 industries, adjusting for smoking and alcohol. Men (1,457 cases) and women (394 cases) were analyzed separately and we incorporated a semi-Bayes adjustment approach for multiple comparisons. Among men, we found increased risks for occupational categories previously reported to be associated with at least one type of UADT cancer, including painters (OR = 1.74, 95% CI: 1.01-3.00), bricklayers (1.58, 1.05-2.37), workers employed in the erection of roofs and frames (2.62, 1.08-6.36), reinforced concreters (3.46, 1.11-10.8), dockers (2.91, 1.05-8.05) and workers employed in the construction of roads (3.03, 1.23-7.46), general construction of buildings (1.44, 1.12-1.85) and cargo handling (2.60, 1.17-5.75). With the exception of the first three categories, risks both increased when restricting to long duration of employment and remained elevated after semi-Bayes adjustment. Increased risks were also found for loggers (3.56, 1.20-10.5) and cattle and dairy farming (3.60, 1.15-11.2). Among women, there was no clear evidence of increased risks of UADT cancer in association with occupations or industrial activities. This study provides evidence of an association between some occupational categories and UADT cancer risk among men. The most consistent findings, also supported by previous studies, were obtained for specific workers employed in the construction industry.
Language
en
Citation
Occupation and risk of upper aerodigestive tract cancer: the ARCAGE study. 2012, 130 (10):2397-406 Int. J. Cancer
ISSN
1097-0215
eISSN
ISBN
DOI
10.1002/ijc.26237
PMID
21671472
PMCID
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