Publication

The regulation of cell growth and survival by aldosterone.

Dooley, Ruth
; 
Harvey, Brian J
; 
Thomas, Warren
Citations
Altmetric:
Author
Dooley, Ruth
 Harvey, Brian J
 Thomas, Warren
Advisors
Editors
Other Contributors
Departments
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education, and Research Centre, Beaumont Hospital, Dublin 9, Ireland. ruthdooley@rcsi.ie
Date
2012-02-01T10:01:25Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
11-beta-Hydroxysteroid Dehydrogenase Type 2
Aldosterone/*physiology
Animals
Blood Vessels/physiology
Brain/drug effects/physiopathology
Cardiovascular Diseases/physiopathology
Cell Differentiation/drug effects
Cell Proliferation/drug effects
Cell Survival/drug effects
Humans
Kidney/drug effects/physiopathology
Kidney Diseases/physiopathology
MAP Kinase Signaling System/physiology
Myocytes, Cardiac/physiology
Nephrons/drug effects/growth & development
Receptors, Aldosterone/physiology
Receptors, Glucocorticoid/physiology
Receptors, Mineralocorticoid/drug effects/*physiology
Renin-Angiotensin System/physiology
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
URI
https://hdl.handle.net/10147/207187
Abstract
The steroid hormone aldosterone is synthesized from cholesterol, mainly in the zona glomerulosa of the adrenal cortex. Aldosterone exerts its effects in the epithelial tissues of the kidney and colon and in non-epithelial tissues such as the brain and cardiovasculature. The genomic response to aldosterone involves dimerization of the mineralocorticoid receptor (MR), dissociation of heat shock proteins from MR, translocation of the aldosterone-MR complex to the nucleus and the concomitant regulation of gene expression. Rapid responses to aldosterone occur within seconds to minutes, do not involve transcription or translation and can modulate directly or indirectly the later genomic responses. Aside from the well-known effects of aldosterone on the regulation of sodium and water homeostasis, aldosterone can also produce deleterious structural changes in tissues by inducing hypertrophy and the dysregulation of proliferation and apoptosis, leading to fibrosis and tissue remodelling. Here we discuss the involvement of aldosterone-mediated rapid signalling cascades in the development of disease states such as chronic kidney disease and heart failure, and the antagonists that can inhibit these pathophysiological responses.
Language
eng
Citation
Front Biosci. 2011 Jan 1;16:440-57.
ISSN
1093-4715 (Electronic)
1093-4715 (Linking)
eISSN
ISBN
DOI
PMID
21196180
PMCID
Sponsorships
Funding Sources
Funding Amounts
Grant Identifiers
Methodology
Duration
Ethical Approval
Embedded videos