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Perioperative anaphylaxis.
Mertes, P M Tajima, K Regnier-Kimmoun, M A Lambert, M Iohom, G Guéant-Rodriguez, R M Malinovsky, J M
Mertes, P M
Tajima, K
Regnier-Kimmoun, M A
Lambert, M
Iohom, G
Guéant-Rodriguez, R M
Malinovsky, J M
Advisors
Editors
Other Contributors
Date
2010-07
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adrenergic Agonists
Analgesics, Opioid
Anaphylaxis
Anesthesia
Anesthetics, Local
Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Aprotinin
Basophils
Epinephrine
Fluid Therapy
Humans
Hypnotics and Sedatives
Immunoglobulin E
Intraoperative Complications
Latex
Neuromuscular Blocking Agents
Risk Factors
Serine Proteinase Inhibitors
Skin Tests
Tryptases
Analgesics, Opioid
Anaphylaxis
Anesthesia
Anesthetics, Local
Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Aprotinin
Basophils
Epinephrine
Fluid Therapy
Humans
Hypnotics and Sedatives
Immunoglobulin E
Intraoperative Complications
Latex
Neuromuscular Blocking Agents
Risk Factors
Serine Proteinase Inhibitors
Skin Tests
Tryptases
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
The incidence of immune-mediated anaphylaxis during anesthesia ranges from 1 in 10,000 to 1 in 20,000. Neuromuscular blocking agents are most frequently incriminated, followed by latex and antibiotics, although any drug or substance used may be a culprit. Diagnosis relies on tryptase measurements at the time of the reaction and skin tests, specific immunoglobulin E, or basophil activation assays. Treatment consists of rapid volume expansion and epinephrine administration titrated to symptom severity.
Language
en
ISSN
1557-9859
eISSN
ISBN
DOI
10.1016/j.mcna.2010.04.002
PMID
20609862