Publication

Amyotrophic lateral sclerosis associated with pregnancy.

Tyagi, A
; 
Sweeney, B J
; 
Connolly, S
Author
Tyagi, A
 Sweeney, B J
 Connolly, S
Advisors
Editors
Other Contributors
Departments
Department of Neurology, Cork University Hospital, Wilton, Cork, Ireland., atyagi@gofree.indigo.ie
Date
2012-02-03T15:10:56Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Amyotrophic Lateral Sclerosis/*diagnosis/drug therapy/*physiopathology
Electromyography
Female
Humans
Magnetic Resonance Imaging
Neuroprotective Agents/therapeutic use
Pregnancy
Pregnancy Complications/*diagnosis/drug therapy/*physiopathology
Riluzole/therapeutic use
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
URI
https://hdl.handle.net/10147/209051
Abstract
Amyotrophic lateral sclerosis (ALS) is the most common, progressive motor neurone disease but is rare in the obstetric population. Only 4 cases have been described in the English literature since 1975. We describe a 29 year old woman who presented with ataxia, lower limb weakness and dysarthria 4 weeks after the birth of her first child. The symptoms had onset during the pregnancy but had not been considered remarkable. There were clinical features of upper and lower motor neurone involvement without any sensory loss. MRI of brain and spine was normal. CSF analysis was negative. EMG studies confirmed the presence of widespread anterior horn cell dysfunction compatible with ALS. The patient was commenced on Riluzole and has progressed clinically, at 12 months post diagnosis.
Language
eng
Citation
Neurol India. 2001 Dec;49(4):413-4.
ISSN
0028-3886 (Print)
0028-3886 (Linking)
eISSN
ISBN
DOI
PMID
11799421
PMCID
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Funding Amounts
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Ethical Approval