The Discriminative validity of "nociceptive," "peripheral neuropathic," and "central sensitization" as mechanisms-based classifications of musculoskeletal pain.
Smart, Keith M Blake, Catherine Staines, Anthony Doody, Catherine
Smart, Keith M
Blake, Catherine
Staines, Anthony
Doody, Catherine
Advisors
Editors
Other Contributors
Date
2012-02-01T10:35:26Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Aged
Aged, 80 and over
Central Nervous System Sensitization/*physiology
Cross-Sectional Studies
Female
Humans
Logistic Models
Low Back Pain/*physiopathology
Male
Middle Aged
Multivariate Analysis
Musculoskeletal Pain/*classification/*diagnosis
Pain Measurement/methods
Peripheral Nervous System Diseases/*diagnosis/physiopathology
Questionnaires
Reproducibility of Results
Sensitivity and Specificity
Young Adult
Aged
Aged, 80 and over
Central Nervous System Sensitization/*physiology
Cross-Sectional Studies
Female
Humans
Logistic Models
Low Back Pain/*physiopathology
Male
Middle Aged
Multivariate Analysis
Musculoskeletal Pain/*classification/*diagnosis
Pain Measurement/methods
Peripheral Nervous System Diseases/*diagnosis/physiopathology
Questionnaires
Reproducibility of Results
Sensitivity and Specificity
Young Adult
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
OBJECTIVES: Empirical evidence of discriminative validity is required to justify the use of mechanisms-based classifications of musculoskeletal pain in clinical practice. The purpose of this study was to evaluate the discriminative validity of mechanisms-based classifications of pain by identifying discriminatory clusters of clinical criteria predictive of "nociceptive," "peripheral neuropathic," and "central sensitization" pain in patients with low back (+/- leg) pain disorders. METHODS: This study was a cross-sectional, between-patients design using the extreme-groups method. Four hundred sixty-four patients with low back (+/- leg) pain were assessed using a standardized assessment protocol. After each assessment, patients' pain was assigned a mechanisms-based classification. Clinicians then completed a clinical criteria checklist indicating the presence/absence of various clinical criteria. RESULTS: Multivariate analyses using binary logistic regression with Bayesian model averaging identified a discriminative cluster of 7, 3, and 4 symptoms and signs predictive of a dominance of "nociceptive," "peripheral neuropathic," and "central sensitization" pain, respectively. Each cluster was found to have high levels of classification accuracy (sensitivity, specificity, positive/negative predictive values, positive/negative likelihood ratios). DISCUSSION: By identifying a discriminatory cluster of symptoms and signs predictive of "nociceptive," "peripheral neuropathic," and "central" pain, this study provides some preliminary discriminative validity evidence for mechanisms-based classifications of musculoskeletal pain. Classification system validation requires the accumulation of validity evidence before their use in clinical practice can be recommended. Further studies are required to evaluate the construct and criterion validity of mechanisms-based classifications of musculoskeletal pain.
Language
eng
ISSN
1536-5409 (Electronic)
0749-8047 (Linking)
0749-8047 (Linking)
eISSN
ISBN
DOI
10.1097/AJP.0b013e318215f16a
PMID
21471812