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Multimodal treatment of perianal fistulas in Crohn's disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial.
de Groof, E Joline Buskens, Christianne J Ponsioen, Cyriel Y Dijkgraaf, Marcel G W D'Haens, Geert R A M Srivastava, Nidhi van Acker, Gijs J D Jansen, Jeroen M Gerhards, Michael F Dijkstra, Gerard
de Groof, E Joline
Buskens, Christianne J
Ponsioen, Cyriel Y
Dijkgraaf, Marcel G W
D'Haens, Geert R A M
Srivastava, Nidhi
van Acker, Gijs J D
Jansen, Jeroen M
Gerhards, Michael F
Dijkstra, Gerard
Author
de Groof, E Joline
Buskens, Christianne J
Ponsioen, Cyriel Y
Dijkgraaf, Marcel G W
D'Haens, Geert R A M
Srivastava, Nidhi
van Acker, Gijs J D
Jansen, Jeroen M
Gerhards, Michael F
Dijkstra, Gerard
Lange, Johan F M
Witteman, Ben J M
Kruyt, Philip M
Pronk, Apollo
van Tuyl, Sebastiaan A C
Bodelier, Alexander
Crolla, Rogier M P H
West, Rachel L
Vrijland, Wietske W
Consten, Esther C J
Brink, Menno A
Tuynman, Jurriaan B
de Boer, Nanne K H
Breukink, Stephanie O
Pierik, Marieke J
Oldenburg, Bas
van der Meulen, Andrea E
Bonsing, Bert A
Spinelli, Antonino
Danese, Silvio
Sacchi, Matteo
Warusavitarne, Janindra
Hart, Ailsa
Yassin, Nuha A
Kennelly, Rory P
Cullen, Garret J
Winter, Desmond C
Hawthorne, A Barney
Torkington, Jared
Bemelman, Willem A
Buskens, Christianne J
Ponsioen, Cyriel Y
Dijkgraaf, Marcel G W
D'Haens, Geert R A M
Srivastava, Nidhi
van Acker, Gijs J D
Jansen, Jeroen M
Gerhards, Michael F
Dijkstra, Gerard
Lange, Johan F M
Witteman, Ben J M
Kruyt, Philip M
Pronk, Apollo
van Tuyl, Sebastiaan A C
Bodelier, Alexander
Crolla, Rogier M P H
West, Rachel L
Vrijland, Wietske W
Consten, Esther C J
Brink, Menno A
Tuynman, Jurriaan B
de Boer, Nanne K H
Breukink, Stephanie O
Pierik, Marieke J
Oldenburg, Bas
van der Meulen, Andrea E
Bonsing, Bert A
Spinelli, Antonino
Danese, Silvio
Sacchi, Matteo
Warusavitarne, Janindra
Hart, Ailsa
Yassin, Nuha A
Kennelly, Rory P
Cullen, Garret J
Winter, Desmond C
Hawthorne, A Barney
Torkington, Jared
Bemelman, Willem A
Advisors
Editors
Other Contributors
Departments
Date
20/08/2015
Date Submitted
Keywords
GASTROINTESTINAL DISORDERS
Other Subjects
Subject Mesh
6-Mercaptopurine
Anti-Inflammatory Agents
Combined Modality Therapy
Cost-Benefit Analysis
Crohn Disease
Digestive System Surgical Procedures
Drainage
Drug Therapy, Combination
Europe
Gastrointestinal Agents
Health Care Costs
Humans
Magnetic Resonance Imaging
Quality of Life
Rectal Fistula
Surveys and Questionnaires
Time Factors
Treatment Outcome
Tumor Necrosis Factor-alpha
Anti-Inflammatory Agents
Combined Modality Therapy
Cost-Benefit Analysis
Crohn Disease
Digestive System Surgical Procedures
Drainage
Drug Therapy, Combination
Europe
Gastrointestinal Agents
Health Care Costs
Humans
Magnetic Resonance Imaging
Quality of Life
Rectal Fistula
Surveys and Questionnaires
Time Factors
Treatment Outcome
Tumor Necrosis Factor-alpha
Planned Date
Start Date
Collaborators
Principal Investigators
Files
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OA Article
Adobe PDF, 731.8 KB
Alternative Titles
Publisher
Abstract
Currently there is no guideline for the treatment of patients with Crohn's disease and high perianal fistulas. Most patients receive anti-TNF medication, but no long-term results of this expensive medication have been described, nor has its efficiency been compared to surgical strategies. With this study, we hope to provide treatment consensus for daily clinical practice with reduction in costs.
Language
en
ISSN
1745-6215
eISSN
ISBN
DOI
10.1186/s13063-015-0831-x
PMID
26289163