Publication

Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia.

Doherty, Anne
; 
Carvalho, Jose C A
; 
Drewlo, Sascha
; 
El-Khuffash, Afif
; 
Downey, Kristi
; 
Dodds, Madelaine
; 
Kingdom, John
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Author
Doherty, Anne
 Carvalho, Jose C A
 Drewlo, Sascha
 El-Khuffash, Afif
 Downey, Kristi
 Dodds, Madelaine
 Kingdom, John
Advisors
Editors
Other Contributors
Departments
Department of Anesthesia, Mount Sinai Hospital, University of Toronto, Toronto ON.
Date
2014-08
Date Submitted
Keywords
PREGNANCY
Other Subjects
PRE-ECLAMPSIA
HYPERURICEMIA
Subject Mesh
Biological Markers
Cohort Studies
Female
Hemodynamics
Humans
Hyperuricemia
Pre-Eclampsia
Pregnancy
Pregnancy Proteins
Vascular Endothelial Growth Factor Receptor-1
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
URI
https://hdl.handle.net/10147/346521
Abstract
Early identification of women at risk of developing early-onset severe preeclampsia (sPE) is a key objective in obstetrics. An elevated ratio of serum soluble fms-like tyrosine kinase (sFlt-1) to placenta-like growth factor (PlGF) (sFlt-1/PlGF ratio) precedes overt hypertension. The longitudinal relationship between this biomarker, maternal hemodynamics, and maternal serum uric acid during the pre-clinical phase is unknown.
Language
en
Citation
Doherty, A. et al., 2014. Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia. Journal of Obstetrics and Gynaecology Canada, 36 (8):692-700
ISSN
1701-2163
eISSN
ISBN
DOI
PMID
25222164
PMCID
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