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Nanodrug applications in photodynamic therapy.
Paszko, Edyta Ehrhardt, Carsten Senge, Mathias O Kelleher, Dermot P Reynolds, John V
Paszko, Edyta
Ehrhardt, Carsten
Senge, Mathias O
Kelleher, Dermot P
Reynolds, John V
Advisors
Editors
Other Contributors
Date
2011-03
Date Submitted
Keywords
Other Subjects
Subject Mesh
Animals
Drug Compounding
Humans
Nanocapsules
Nanomedicine
Photochemotherapy
Drug Compounding
Humans
Nanocapsules
Nanomedicine
Photochemotherapy
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Photodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for the treatment of various diseases such as cancer and macular degeneration. It is a two-step technique in which the delivery of a photosensitizing drug is followed by the irradiation of light. Activated photosensitizers transfer energy to molecular oxygen which results in the generation of reactive oxygen species which in turn cause cells apoptosis or necrosis. Although this modality has significantly improved the quality of life and survival time for many cancer patients it still offers significant potential for further improvement. In addition to the development of new PDT drugs, the use of nanosized carriers for photosensitizers is a promising approach which might improve the efficiency of photodynamic activity and which can overcome many side effects associated with classic photodynamic therapy. This review aims at highlighting the different types of nanomedical approaches currently used in PDT and outlines future trends and limitations of nanodelivery of photosensitizers.
Language
en
ISSN
1873-1597
eISSN
ISBN
DOI
10.1016/j.pdpdt.2010.12.001
PMID
21333931