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Interferon gamma release assays for the diagnosis of latent TB infection in HIV-infected individuals in a low TB burden country.
Cheallaigh, Clíona Ní Fitzgerald, Ian Grace, Jacinta Singh, Gurmit Jagjit El-Eraki, Nahla Gibbons, Noel Keane, Joseph Rogers, Thomas R Clarke, Susan Bergin, Colm
Cheallaigh, Clíona Ní
Fitzgerald, Ian
Grace, Jacinta
Singh, Gurmit Jagjit
El-Eraki, Nahla
Gibbons, Noel
Keane, Joseph
Rogers, Thomas R
Clarke, Susan
Bergin, Colm
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Date
2013-01
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journalpone00533301.pdf
Adobe PDF, 253.54 KB
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Abstract
Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting.
Language
en
ISSN
1932-6203
eISSN
ISBN
DOI
10.1371/journal.pone.0053330
PMID
23382842