Daily diurnal variation in admissions for ruptured abdominal aortic aneurysms.
Killeen, Shane Neary, Peter O'Sullivan, Martin Redmond, H P Fulton, Gregory
Killeen, Shane
Neary, Peter
O'Sullivan, Martin
Redmond, H P
Fulton, Gregory
Advisors
Editors
Other Contributors
Date
2012-02-03T15:16:56Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Aged
Aged, 80 and over
Aortic Aneurysm, Abdominal/*epidemiology
Aortic Rupture/*epidemiology
Chi-Square Distribution
*Circadian Rhythm
Cohort Studies
Female
Hospitals, University
Humans
Hypertension/epidemiology
Ireland/epidemiology
Logistic Models
Male
Patient Admission/*statistics & numerical data
Retrospective Studies
Risk Factors
Aged, 80 and over
Aortic Aneurysm, Abdominal/*epidemiology
Aortic Rupture/*epidemiology
Chi-Square Distribution
*Circadian Rhythm
Cohort Studies
Female
Hospitals, University
Humans
Hypertension/epidemiology
Ireland/epidemiology
Logistic Models
Male
Patient Admission/*statistics & numerical data
Retrospective Studies
Risk Factors
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
BACKGROUND: Many vascular events, such as myocardial infarction and cerebrovascular accident, demonstrate a circadian pattern of presentation. Blood pressure is intimately related to these pathologies and is the one physiological variable consistently associated with abdominal aortic aneurysm rupture. It also demonstrates a diurnal variation. The purpose of this study was to determine if rupture of an abdominal aortic aneurysm (RAAA) exhibits a diurnal variation. METHODS: A retrospective cohort-based study was performed to determine the timing of presentation of RAAA to the vascular unit of Cork University Hospital over a 15-year period. Time of admission, symptom onset, and co-morbidities such as hypertension were noted. Fournier's analysis and chi-squared analysis were performed. To ameliorate possible confounding factors, patients admitted with perforated peptic ulcers were examined in the same manner. RESULTS: A total of 148 cases of RAAA were identified, with a male preponderance (71.7% [124] male versus 29.3% [44] female patients) and a mean age of 74.4 +/- 7.2 years at presentation. 70.9% (105) were known to have hypertension, 52.2% (77) were current smokers, and 46.8% (69) were being treated for chronic obstructive airway disease (COAD). Time of symptom onset was recorded in 88.5% (131) of patients. There was a marked early morning peak in RAAA admissions, with the highest number of RAAA being admitted between 08.00 and 09.59. A second, smaller peak was observed at 14.00-15.59. These findings were suggestive of diurnal variation. [chi(2) =16.75, p < 0.003]. Some 40% (59) of patients were admitted between 00.00 and 06.00, an incidence significantly higher than for other time periods (06.00-12.00, 12.00-18.00, and 18.00-24.00) [chi(2) = 18.72; df = 3; p < 0.0003]. A significantly higher number of patients admitted between 00.00 and 06.00 were known hypertensives (chi(2) = 7.94; p < 0.05). CONCLUSIONS: The findings of this study suggest a distinct circadian pattern of presentation for RAAA. Systolic blood pressure has a circadian rhythm that mirrors this pattern of presentation. Our results further support the association between RAAA and hypertension, and they may also indicate that chronotropic blood pressure control combating the early-morning peak in systolic blood pressure may assist in the management of abdominal aortic aneurysms.
Language
eng
ISSN
0364-2313 (Print)
0364-2313 (Linking)
0364-2313 (Linking)
eISSN
ISBN
DOI
10.1007/s00268-007-9126-z
PMID
17571206