Lack of association between folate-receptor autoantibodies and neural-tube defects.

Hdl Handle:
http://hdl.handle.net/10147/94213
Title:
Lack of association between folate-receptor autoantibodies and neural-tube defects.
Authors:
Molloy, Anne M; Quadros, Edward V; Sequeira, Jeffrey M; Troendle, James F; Scott, John M; Kirke, Peadar N; Mills, James L
Affiliation:
School of Medicine, Trinity College, Dublin, Ireland. amolloy@tcd.ie
Citation:
Lack of association between folate-receptor autoantibodies and neural-tube defects. 2009, 361 (2):152-60 N. Engl. J. Med.
Journal:
The New England journal of medicine
Issue Date:
9-Jul-2009
URI:
http://hdl.handle.net/10147/94213
DOI:
10.1056/NEJMoa0803783
PubMed ID:
19587340
Abstract:
BACKGROUND: A previous report described the presence of autoantibodies against folate receptors in 75% of serum samples from women with a history of pregnancy complicated by a neural-tube defect, as compared with 10% of controls. We sought to confirm this finding in an Irish population, which traditionally has had a high prevalence of neural-tube defects. METHODS: We performed two studies. Study 1 consisted of analysis of stored frozen blood samples collected from 1993 through 1994 from 103 mothers with a history of pregnancy complicated by a neural-tube defect (case mothers), 103 mothers with a history of pregnancy but no complication by a neural-tube defect (matched with regard to number of pregnancies and sampling dates), 58 women who had never been pregnant, and 36 men. Study 2, conducted to confirm that the storage of samples did not influence the folate-receptor autoantibodies, included fresh samples from 37 case mothers, 22 control mothers, 10 women who had never been pregnant, and 9 men. All samples were assayed for blocking and binding autoantibodies against folate receptors. RESULTS: In Study 1, blocking autoantibodies were found in 17% of case mothers, as compared with 13% of control mothers (odds ratio, 1.54; 95% confidence interval [CI], 0.70 to 3.39), and binding autoantibodies in 29%, as compared with 32%, respectively (odds ratio, 0.82; 95% CI, 0.44 to 1.50). Study 2 showed similar results, indicating that sample degradation was unlikely. CONCLUSIONS: The presence and titer of maternal folate-receptor autoantibodies were not significantly associated with a neural-tube defect-affected pregnancy in this Irish population.
Language:
en
MeSH:
Autoantibodies; Carrier Proteins; Case-Control Studies; Female; Humans; Ireland; Logistic Models; Male; Neural Tube Defects; Pregnancy; Receptors, Cell Surface
ISSN:
1533-4406

Full metadata record

DC FieldValue Language
dc.contributor.authorMolloy, Anne Men
dc.contributor.authorQuadros, Edward Ven
dc.contributor.authorSequeira, Jeffrey Men
dc.contributor.authorTroendle, James Fen
dc.contributor.authorScott, John Men
dc.contributor.authorKirke, Peadar Nen
dc.contributor.authorMills, James Len
dc.date.accessioned2010-03-12T15:38:18Z-
dc.date.available2010-03-12T15:38:18Z-
dc.date.issued2009-07-09-
dc.identifier.citationLack of association between folate-receptor autoantibodies and neural-tube defects. 2009, 361 (2):152-60 N. Engl. J. Med.en
dc.identifier.issn1533-4406-
dc.identifier.pmid19587340-
dc.identifier.doi10.1056/NEJMoa0803783-
dc.identifier.urihttp://hdl.handle.net/10147/94213-
dc.description.abstractBACKGROUND: A previous report described the presence of autoantibodies against folate receptors in 75% of serum samples from women with a history of pregnancy complicated by a neural-tube defect, as compared with 10% of controls. We sought to confirm this finding in an Irish population, which traditionally has had a high prevalence of neural-tube defects. METHODS: We performed two studies. Study 1 consisted of analysis of stored frozen blood samples collected from 1993 through 1994 from 103 mothers with a history of pregnancy complicated by a neural-tube defect (case mothers), 103 mothers with a history of pregnancy but no complication by a neural-tube defect (matched with regard to number of pregnancies and sampling dates), 58 women who had never been pregnant, and 36 men. Study 2, conducted to confirm that the storage of samples did not influence the folate-receptor autoantibodies, included fresh samples from 37 case mothers, 22 control mothers, 10 women who had never been pregnant, and 9 men. All samples were assayed for blocking and binding autoantibodies against folate receptors. RESULTS: In Study 1, blocking autoantibodies were found in 17% of case mothers, as compared with 13% of control mothers (odds ratio, 1.54; 95% confidence interval [CI], 0.70 to 3.39), and binding autoantibodies in 29%, as compared with 32%, respectively (odds ratio, 0.82; 95% CI, 0.44 to 1.50). Study 2 showed similar results, indicating that sample degradation was unlikely. CONCLUSIONS: The presence and titer of maternal folate-receptor autoantibodies were not significantly associated with a neural-tube defect-affected pregnancy in this Irish population.-
dc.language.isoenen
dc.subject.meshAutoantibodies-
dc.subject.meshCarrier Proteins-
dc.subject.meshCase-Control Studies-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshLogistic Models-
dc.subject.meshMale-
dc.subject.meshNeural Tube Defects-
dc.subject.meshPregnancy-
dc.subject.meshReceptors, Cell Surface-
dc.titleLack of association between folate-receptor autoantibodies and neural-tube defects.en
dc.contributor.departmentSchool of Medicine, Trinity College, Dublin, Ireland. amolloy@tcd.ieen
dc.identifier.journalThe New England journal of medicineen

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